gene 757 words KG: BAG2 2026-03-22
kind:genesection:genesstate:published
Contents

BAG2

🧬 Gene Info
Gene SymbolBAG2
Protein TypeChaperone
FunctionBAG2 (BCL2 Associated Athanogene 2) is a co-chaperone protein that modulates the Hsp70/Hsp90 chaperone systems.
Molecular Weight22.5 kDa
Amino Acids211 aa
PathwaysProteasome
Ensembl IDENSG00000165168
GeneCardsBAG2
Human Protein AtlasBAG2
IPO2005 (TSE: 4568)
Market Cap~$70B (2026)
2025 Revenue¥1.5T
Associated DiseasesMs
InteractionsSQSTM1, P62, AUTOPHAGY, TAU, UBIQUITIN
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50
Cryptic Exon Silencing Restoration
Score: 0.46

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Ubiquitin
protein · KG edge: activates
Tau Protein
protein · KG edge: activates
p62 - Sequestosome 1 (SQSTM1)
protein · KG edge: interacts_with
Tau Consortium
organization · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates

Knowledge Graph (12 edges)

BAG2 interacts_with SQSTM1
BAG2 interacts_with P62
BAG2 associated_with BCL2
BAG2 associated_with Ms
BAG2 activates Proteasome
BAG2 inhibits Autophagy
BAG2 regulates Aging
BAG2 regulates Ms
BAG2 inhibits AUTOPHAGY
BCL2 associated_with BAG2