gene 2,581 words KG: SQSTM1 2026-03-24
kind:genesection:genesstate:published
Contents

SQSTM1 — Sequestosome 1 (p62)

🧬 Gene Info
Gene SymbolSQSTM1
Full NameSequestosome 1 (p62)
Chromosome5q35.3
Protein TypeProtein
Functionp62/SQSTM1 functions as: [@jones2021]
Molecular Weight~62 kDa (hence p62)
PathwaysAdaptive Immunity, Akt, Autophagy, Autophagy-lysosomal pathway, Cell Cycle
UniProt IDQ13501
NCBI Gene ID8878
Ensembl IDENSG00000161011
OMIM601530
GeneCardsSQSTM1
Human Protein AtlasSQSTM1
Associated DiseasesAD, ADH, ALI, ALS, AMI, ARM
Known Drugs/CompoundsRAPAMYCIN, Ubiquitinated Proteins, Ubiquitinated Cargo, Ubiquitinated Substrates, statins, COENZYME Q10
InteractionsABCA1, APOE, LOX, NDP52, TAX1BP1, FUS
KG Connections4026 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Autophagosome Maturation Checkpoint Control
Score: 0.49
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
VCP-Mediated Autophagy Enhancement
Score: 0.41
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66

Related Analyses (21)

What determines the spatial organization of autophagy recept
neurodegeneration · failed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (13)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85
P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85

See Also (5)

Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
ACTB Gene
gene · KG edge: activates
ABCG1 Gene
gene · KG edge: interacts_with
ABCD3 Gene
gene · KG edge: interacts_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates

Knowledge Graph (12 edges)

SQSTM1 associated_with PINK1
SQSTM1 associated_with STAT3
SQSTM1 associated_with JUN
SQSTM1 associated_with NRF2
SQSTM1 associated_with BDNF
SQSTM1 co_discussed STING
SQSTM1 co_discussed TARDBP
SQSTM1 co_discussed TDP-43
SQSTM1 causes ULK1
SQSTM1 co_discussed TLR4