protein 643 words KG: C1QAPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

C1qA Protein

🔬 Protein Info
Gene SymbolC1QAPROTEIN
Full NameC1qA
Protein TypeProtein
Target ClassSignaling Protein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Mechanism of ActionComplement cascade inhibitor or antibody-mediated neutralization
DruggabilityLow (0.41)
Clinical StagePhase II
UniProt IDSearch UniProt
GeneCardsC1QAPROTEIN
Human Protein AtlasC1QAPROTEIN
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/CompoundsANX005
InteractionsSPP1, GRN, C1QC, CTSB, C1Q, CLU
SciDEX TargetView Target Profile (7 clinical trials)
SciDEX HypothesesComplement C1q Suppression as Mechanism Linking Ex
Complement C1q Mimetic Decoy Therapy
Complement C1q Subtype Switching (+3 more)
KG Connections705 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.48
Synaptic Pruning Precision Therapy
Score: 0.47
Complement C1q Subtype Switching
Score: 0.44
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43

Related Analyses (16)

What are the specific molecular mechanisms by which C1Q comp
neuroinflammation · failed
How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completed
Mechanistic validation of SEA-AD differential expression hyp
neurodegeneration · failed
Do these mechanistic hypotheses explain layer-specific synap
neurodegeneration · failed
Do these mechanistic hypotheses from the SEA-AD Atlas bundle
neurodegeneration · failed

Related Experiments (8)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses