protein 1,289 words KG: COX15 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

COX15 Protein

🔬 Protein Info
Gene SymbolCOX15
Full NameCytochrome C Oxidase Assembly Factor 15
Chromosome10q24.2
Protein FamilyHeme A biosynthesis family
FunctionCOX15 plays a crucial role in the final steps of heme A synthesis
Primary Expressionall tissues with high energy demands: - Heart and skeletal muscle (highest expression) - Brain (neurons and glia) - Liver and kid
Subcellular LocalizationMitochondrial inner membrane
Molecular Weight42 kDa
UniProt IDQ7B433
Ensembl IDENSG00000074981
OMIM603646
GeneCardsCOX15
Human Protein AtlasCOX15
Protein NameCytochrome C Oxidase Assembly Factor 15
Enzyme ActivityHeme O to heme A conversion (Cox15 hydroxylase)
Associated Diseasesneurodegeneration
InteractionsCOX4I1, COX7A1, COX8A, NDUFA12, NDUFA5, NDUFS1
KG Connections21 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
VPS33A Gene
gene · KG edge: associated_with
VPS16 Gene
gene · KG edge: associated_with
RPL4 — Ribosomal Protein L4
gene · KG edge: associated_with
PPP1R7 — SDS22 (Protein Phosphatase 1 Regulatory Subuni
gene · KG edge: associated_with

Knowledge Graph (12 edges)

COX15 associated_with RPL4
COX15 co_expressed_with COX4I1
COX15 co_expressed_with COX7A1
COX15 inhibits COX4I1
COX15 inhibits COX7A1
COX15 inhibits COX8A
COX15 inhibits NDUFA12
COX15 inhibits NDUFA5
COX15 inhibits NDUFS1
COX15 inhibits NDUFS4