| Gene Symbol | DISC1 |
| Full Name | Disrupted in Schizophrenia 1 |
| Chromosome | 1q42.2 |
| Protein Family | DISC1 family (no known homologs outside vertebrates) |
| Protein Type | Scaffold Protein |
| Function | Centrosomal function: DISC1 localizes to the centrosome where it interacts with NDEL1, LIS1, and dynein to regulate neuronal migration during cortical development |
| Primary Expression | Hippocampus, Cerebral cortex, Cerebellum, Dentate gyrus |
| Subcellular Localization | Centrosome, mitochondria, postsynaptic density, nucleus |
| Exons | 13 |
| Pathways | Akt, Apoptosis, Complement, Exocytosis, Mitochondrial Function |
| UniProt ID | Q9NRI5 |
| NCBI Gene ID | 27185 |
| Ensembl ID | ENSG00000162946 |
| OMIM | 605210 |
| GeneCards | DISC1 |
| Human Protein Atlas | DISC1 |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Amyotrophic Lateral Sclerosis |
| Interactions | EIF2S1, RIPK3, DRP1, CHOP, BECN1, PTEN |
| KG Connections | 772 knowledge graph edges |
| Databases | GeneCardsHPASTRING |