protein 1,324 words KG: FASNPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

FASN Protein

🔬 Protein Info
Gene SymbolFASN
AliasesFASNPROTEIN
Chromosome1q25
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization** | Cytoplasm, Cytosolic |
Molecular Weight273 kDa
PathwaysAkt, Lipid Metabolism, Mtor, Pi3K
Ensembl IDENSG00000169710
GeneCardsFASN
Human Protein AtlasFASN
Associated DiseasesAD, AMI, ARM, Aging, Atherosclerosis, Cancer
InteractionsSRC, HK1, MTOR, PTEN, HK2, BAX
KG Connections365 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses