| Gene Symbol | FYNPROTEIN |
| Chromosome | 6q21. |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons, oligodendrocytes, and astrocytes, where it regulates myelination, synaptic plasticity, and [NMDA |
| Subcellular Localization | through palmitoylation cycles, trafficking between the Golgi apparatus, plasma m |
| Molecular Weight | 59 kDa |
| GeneCards | FYNPROTEIN |
| Human Protein Atlas | FYNPROTEIN |
| Unique domain (residues 1-85) | Contains Fyn-specific sequences that mediate unique protein interactions, including binding to myelin proteins |
| SH3 domain (residues 85-143) | Binds proline-rich motifs; participates in autoinhibitory conformation |
| SH2 domain (residues 150-225) | Binds phosphotyrosine residues on regulatory proteins |
| C-terminal tail | Tyr531 (human) is phosphorylated by CSK for autoinhibition |
| Process extension | Promotes oligodendrocyte process outgrowth and wrapping around axons |
| Fyn knockout phenotype | Mice lacking Fyn show hypomyelination, tremors, and motor coordination deficits (Umemori et al., 1994)[@umemori1994] |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease |
| Interactions | Actin, AD, ADRB2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE |
| SciDEX Hypotheses | FYN-Mediated Extracellular Vesicle Release Inhibit |
| KG Connections | 443 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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