protein 857 words KG: GDNFPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

GDNF Protein

🔬 Protein Info
Gene SymbolGDNF
AliasesGlial Cell Line-Derived Neurotrophic Factor
Protein FamilyGDNF family
FunctionMaintains tyrosine hydroxylase expression
Primary ExpressionSecreted, Extracellular space
Subcellular LocalizationSecreted
Molecular Weight~15 kDa (homodimer)
PathwaysPI3K, MAPK, TGF-β
UniProt IDP39905
GeneCardsGDNF
Human Protein AtlasGDNF
GeneGDNF
Associated DiseasesALS, APOPTOSIS, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/Compoundslevodopa, trehalose, rapamycin
InteractionsGFRAL, BDNF, GLP1R, SHH, ADCY3, LMX1A
SciDEX HypothesesGDNF Gradient Establishment by Schwann Cells Enabl
KG Connections779 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53
Purinergic Signaling Polarization Control
Score: 0.55
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in