Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adcy3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADCY3 |
| Full Name | Adenylate cyclase 3 |
| Chromosome | 2p23.3 |
| Protein Type | Enzyme |
| Function | is a member of the adenylate cyclase family of enzymes that catalyze the conversion of ATP to cyclic AMP (cAMP), a ubiquitous second messenger critical for cellular signaling. |
| Primary Expression | olfactory sensory neurons where it plays a critical role in odor detection and signal transduction |
| Molecular Weight | 140 kDa |
| Amino Acids | 244 aa |
| UniProt ID | [O60236](https://www.uniprot.org/uniprot/O60236) |
| Ensembl ID | ENSG00000138031 |
| OMIM | 600019 |
| GeneCards | ADCY3 |
| Human Protein Atlas | ADCY3 |
| Associated Diseases | obesity, Alzheimer's Disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ADCY3"]
N1["Als"]
N0 -->|"activates"| N1
N2["Ms"]
N0 -->|"activates"| N2
N3["Hedgehog"]
N0 -->|"activates"| N3
N4["HDAC6"]
N0 -->|"activates"| N4
N5["SHH"]
N0 -->|"activates"| N5
N6["GFRAL"]
N0 -->|"activates"| N6
N7["GDNF"]
N0 -->|"activates"| N7
N8["HEDGEHOG"]
N0 -->|"activates"| N8
N4 -->|"activates"| N0
N7 -->|"activates"| N0
N5 -->|"activates"| N0
N6 -->|"activates"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 disease
class N3 pathway
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| HDAC6 | activates | gene | 0.60 |
| SHH | activates | gene | 0.60 |
| GFRAL | activates | gene | 0.60 |
| GDNF | activates | gene | 0.60 |
| LAMP2A | cleaves | gene | 0.60 |
| Hedgehog | activates | pathway | 0.60 |
| HEDGEHOG | activates | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| benchmark_ot_ad_answer_key:ADCY3 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HDAC6 | activates | gene | 0.60 |
| GDNF | activates | gene | 0.60 |
| SHH | activates | gene | 0.60 |
| GFRAL | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADCY3 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||