protein 858 words KG: GPNMBPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

GPNMB Protein

🔬 Protein Info
Gene SymbolGPNMB
Full NameGlycoprotein Nmb
AliasesGPNMBPROTEIN
Chromosome7p15.3
FunctionGPNMB is a type I transmembrane protein with an extracellular domain containing a polycystic kidney disease (PKD) domain and a车位 ITAM-like motif.
Primary Expressionvarious tissues including brain, bone, and immune cells
Subcellular Localization</td><td>Cell surface, endosomes, lysosomes, melanosome-like organelles</td></tr>
Molecular Weight63.5 kDa
Amino Acids572 aa
PathwaysAutophagy, Cholesterol, Immune Response, Inflammatory Pathways
UniProt IDQ14990
NCBI Gene ID2690
Ensembl IDENSG00000136235
GeneCardsGPNMB
Human Protein AtlasGPNMB
Associated DiseasesAD, ALI, ALS, Alzheimer, Alzheimer'S Disease
InteractionsHMGB1, C1Q, S100B, TGM2, JUN, APP
KG Connections451 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (21)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses