protein 810 words KG: HEXBPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Hexosaminidase B (Hex B) Protein

🔬 Protein Info
Gene SymbolHEXBPROTEIN
Protein FamilyGlycoside hydrolase family 20
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationLysosome
Molecular Weight~110 kDa (homodimer)
Amino Acids556 aa
UniProt IDP07604
GeneCardsHEXBPROTEIN
Human Protein AtlasHEXBPROTEIN
infobox[@shyer2003]
Hexosaminidase B (Hex B)[@matsuoka2006]
GeneHEXB
PDB Structures2YJJ, 5G0M
Asialo-GM2Lactosylceramide + GalNAc
GlobosideLactosylceramide
Associated DiseasesALS, Sandhoff Disease, disease, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsMTOR, TSC2, Rb, SALL1, TMEM119, LC3
KG Connections98 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Microglial Purinergic Reprogramming
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in