| Gene Symbol | IGF2 |
| Aliases | Insulin-Like Growth Factor 2 |
| Function | IGF2 serves multiple physiological functions |
| Subcellular Localization | </b></td><td>Secreted, extracellular; intracellular stores</td></tr> |
| Molecular Weight | 7.5 kDa |
| Amino Acids | 24 aa |
| Pathways | Blood-Brain Barrier |
| UniProt ID | [P01344](https://www.uniprot.org/uniprot/P01344) |
| NCBI Gene ID | 3481 |
| GeneCards | IGF2 |
| Human Protein Atlas | IGF2 |
| Signal Peptide (1-24) | The N-terminal 24 amino acids direct IGF2 to the secretory pathway, targeting the protein for secretion from the cell. |
| B Domain (25-40) | The B (or E) domain contains the receptor-binding interface and is essential for biological activity. This domain is cleaved during processing to generate the mature peptide. |
| C Peptide (41-82) | The C peptide serves as a connecting peptide between the B and A domains. It is removed during proteolytic processing and is not required for receptor binding. |
| A Domain (83-110) | The A domain forms the C-terminal portion of the mature peptide and contains additional receptor-binding determinants. |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease |
| Interactions | AGING, AKT, AKT1, ALS, ALZHEIMER, amyotrophic lateral sclerosis |
| KG Connections | 185 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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