gene

amyotrophic lateral sclerosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about amyotrophic lateral sclerosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5729Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	amyotrophic lateral sclerosis
Summary	This page has been consolidated into diseases/als
Associated Diseases	Alzheimer Disease, Alzheimer'S Disease, Ataxia, Autoimmune, FRONTOTEMPORAL DEMENTIA, ISCHEMIA
Known Drugs/Compounds	Treahalose
Interactions	MAP1LC3, HUNTINGTON, AMYLOID, Proteins, ACTB, ULK1
KG Connections	456 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SOD1_mutations["SOD1 mutations"] -->|"causes"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    style SOD1_mutations fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TBK1["TBK1"] -->|"risk factor for"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    style TBK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SQSTM1["SQSTM1"] -->|"risk factor for"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SOD1["SOD1"] -->|"causes"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    style SOD1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    OPTN["OPTN"] -->|"risk factor for"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    style OPTN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style amyotrophic_lateral_sclerosis fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (2447)

Target	Relation	Type	Str
MAP1LC3	activates	gene	0.50
TRIM21	activates	concept	0.50
FRONTOTEMPORAL	activates	concept	0.50
FRONTOTEMPORAL DEMENTIA	inhibits	disease	0.50
FRONTOTEMPORAL	inhibits	concept	0.50
NF-κB	activates	concept	0.50
Neuroinflammatory	activates	pathway	0.50
disease	activates	disease	0.50
CYTOKINE	activates	concept	0.50
HUNTINGTON	activates	gene	0.50
Neurodegenerative Diseases	activates	disease	0.50
Spinal Cord	activates	cell_type	0.50
Chaperone	activates	pathway	0.50
PPP3	activates	concept	0.50
Neuroblastoma	activates	disease	0.50
SELECTIVE AUTOPHAGY	activates	concept	0.50
STEM CELLS	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
PEROXISOME	activates	concept	0.50
disease	causes	disease	0.50
NEURODEGENERATIVE DISEASE	causes	concept	0.50
FTLD	associated_with	concept	0.50
FRONTOTEMPORAL	associated_with	concept	0.50
AMYLOID	interacts_with	gene	0.50
Neurodegenerative Diseases	interacts_with	disease	0.50
Alzheimer Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
NEURODEGENERATIVE DISEASE	interacts_with	concept	0.50
SYNUCLEIN	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50
AMYLOID-β	interacts_with	concept	0.50
α-SYNUCLEIN	interacts_with	concept	0.50
Alzheimer'S Disease	associated_with	disease	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
AMYLOID	associated_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
HUNTINGTON	interacts_with	gene	0.50
Parkinson's Disease	interacts_with	disease	0.50
HUNTINGTON'S DISEASE	interacts_with	concept	0.50
ALZHEIMER'S	interacts_with	concept	0.50
PARKINSON'S	interacts_with	concept	0.50
HUNTINGTON'S	interacts_with	concept	0.50
CEREBROSPINAL FLUID	interacts_with	concept	0.50
Neuron	associated_with	cell_type	0.50
MOTOR NEURON	associated_with	concept	0.50
Neuron	causes	cell_type	0.50

Incoming (3282)

Source	Relation	Type	Str
SOD1 mutations	causes	gene	0.95
TBK1	risk_factor_for	gene	0.95
SQSTM1	risk_factor_for	gene	0.92
SOD1	causes	gene	0.90
OPTN	risk_factor_for	gene	0.90
TDP-43	implicated_in	protein	0.90
TBK1	implicated_in	gene	0.90
C9ORF72	implicated_in	gene	0.90
PINK1	risk_factor_for	gene	0.85
STING	associated_with	protein	0.85
TFEB	protects_against	gene	0.85
SQSTM1	associated_with	protein	0.80
HSPa1b	activates	gene	0.80
OPTN	associated_with	gene	0.80
ANXA11	associated_with	gene	0.80
NEAT1	upregulated_in	gene	0.80
IGF2	implicated_in	gene	0.80
MAPK pathway	therapeutic_target	pathway	0.80
PARTHANATOS	implicated_in	process	0.80
STAU2	overabundant_in	protein	0.80
polyunsaturated fatty acids	protective_against	compound	0.80
ASK1	implicated_in	gene	0.80
MICROGLIA	implicated_in	cell_type	0.80
SOD1	implicated_in	gene	0.80
CASP3	implicated_in	gene	0.80
GSDMD	implicated_in	gene	0.80
NPY	implicated_in	gene	0.80
VDAC1	implicated_in	gene	0.80
PGRN	exacerbates	gene	0.80
SOLTNF	implicated_in	protein	0.80
PARP1	implicated_in	gene	0.80
APOE	implicated_in	gene	0.80
insulin resistance	associated_with	process	0.70
stress granules	associated_with	process	0.70
autophagy	protects_against	pathway	0.70
autophagy dysfunction	causes	process	0.70
autophagy-endolysosomal pathway	associated_with	pathway	0.70
CGAS-STING signaling	participates_in	pathway	0.70
ferroptosis	associated_with	process	0.70
NRF2	protects_against	protein	0.70
STING1	activates	protein	0.70
autophagy	associated_with	process	0.70
PPARGC1A	protects_against	gene	0.70
TDP-43	associated_with	protein	0.70
AMPK	associated_with	protein	0.70
necroptosis	associated_with	process	0.70
oxidative stress	causes	process	0.70
TDP-43	biomarker_for	protein	0.70
IGF2	biomarker_for	protein	0.70
lysosomal dysfunction	causes	process	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

amyotrophic lateral sclerosis

Understanding Entity Pages

Wiki Pages (21)