protein 737 words KG: ITPR1 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

ITPR1 Gene

🔬 Protein Info
Gene SymbolITPR1
Full NameInositol 1,4,5-Trisphosphate Receptor Type 1
AliasesPage for ITPR1
Chromosome3p26.1
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight300 kDa
Amino Acids700 aa
Exons58 exons
PathwaysCalcium Dysregulation
UniProt ID[Q14643](https://www.uniprot.org/uniprot/Q14643)
Ensembl IDENSG00000151952
GeneCardsITPR1
Human Protein AtlasITPR1
Chromosomal location3p26.1
Associated DiseasesDiabetes, stroke
KG Connections30 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: associated_with
TIMP1 Gene
gene · KG edge: expressed_in
MAP1LC3B — LC3B
gene · KG edge: expressed_in
IL12B Gene - Interleukin 12 Beta
gene · KG edge: expressed_in
HSPA5 — Heat Shock Protein Family A (Hsp70) Member 5
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ITPR1 expressed_in MAP1LC3B
ITPR1 expressed_in TIMP1
ITPR1 associated_with WIPI1
ITPR1 activates stroke
ITPR1 inhibits stroke
ITPR1 implicated_in stroke
ITPR1 expressed_in GENES
ITPR1 expressed_in Atherosclerosis
ITPR1 expressed_in Autophagy
ITPR1 associated_with Diabetes