gene 802 words KG: HSPA5 2026-03-24
kind:genesection:genesstate:published
Contents

HSPA5 — Heat Shock Protein Family A (Hsp70) Member 5

🧬 Gene Info
Gene SymbolHSPA5
Full NameHeat Shock Protein Family A (Hsp70) Member 5
AliasesHsp70
Chromosome9q33.3
Protein FamilyHsp70 family (ER-resident)
Protein TypeChaperone
FunctionHSPA5/GRP78 is a BiP (Binding Immunoglobulin Protein) that resides in the ER lumen.
Primary Expressionbrain, particularly in neurons and glia
PathwaysAkt, Autophagy, Lipid Metabolism, Wnt
UniProt IDP11021
NCBI Gene ID3309
Ensembl IDENSG00000156006
OMIM138120
GeneCardsHSPA5
Human Protein AtlasHSPA5
Associated DiseasesAging, Atherosclerosis, Diabetes
Known Drugs/Compoundsrapamycin
InteractionsMAVS, FIP200, AMBRA1, APC, ERN1, EIF2AK3
KG Connections489 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50
Lysosomal Enzyme Trafficking Correction
Score: 0.49
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
BECN1 Gene
gene · KG edge: activates
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with
ATF6 - Activating Transcription Factor 6
gene · KG edge: activates

Knowledge Graph (12 edges)

HSPA5 regulates JNK
HSPA5 expressed_in EPITHELIUM
HSPA5 phosphorylates IFNG
HSPA5 phosphorylates JNK
HSPA5 phosphorylates LRRK2
HSPA5 phosphorylates MAP1LC3A
HSPA5 phosphorylates MAPK14
HSPA5 phosphorylates MAVS
HSPA5 phosphorylates MLKL
HSPA5 phosphorylates MLST8