gene 1,135 words KG: ITPR1
Contents

ITPR1 - Inositol 1,4,5-Trisphosphate Receptor Type 1

🧬 Gene Info
Gene SymbolITPR1
Full NameInositol 1,4,5-Trisphosphate Receptor Type 1
AliasesPage for ITPR1
Chromosome3p26.1
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight300 kDa
Amino Acids700 aa
Exons58
PathwaysCalcium Dysregulation
UniProt ID[Q14643](https://www.uniprot.org/uniprot/Q14643)
Ensembl IDENSG00000151952
GeneCardsITPR1
Human Protein AtlasITPR1
IP3 bindingCooperative binding at N-terminus triggers conformational change
Associated DiseasesDiabetes, stroke
KG Connections30 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
Genes
index · KG edge: expressed_in
EIF2AK3 - Eukaryotic Translation Initiation Factor 2 Al
gene · KG edge: associated_with
FOXO3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IL12B expressed_in ITPR1
ITPR1 expressed_in MAP1LC3B
ITPR1 expressed_in TIMP1
RAB7A associated_with ITPR1
GABARAPL2 associated_with ITPR1
FOXO3 associated_with ITPR1
LAMP2 associated_with ITPR1
RB1CC1 associated_with ITPR1
EIF2AK3 associated_with ITPR1
GAPDH associated_with ITPR1

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