gene 1,202 words KG: MAP1LC3B 2026-03-27
kind:genesection:genesstate:published
Contents

MAP1LC3B — LC3B

🧬 Gene Info
Gene SymbolMAP1LC3B
Full NameMicrotubule-associated proteins 1A/1B light chain 3B
AliasesLC3B
Chromosome16q24.2
FunctionMAP1LC3B encodes LC3B, a key protein in the autophagy pathway.
Primary ExpressionUbiquitous, high in brain (neurons and glia), liver, heart, skeletal muscle
Molecular Weight~14.5 kDa
Amino Acids125 aa
PathwaysApoptosis, Autophagy, Immune Response, Innate Immunity, Mapk
UniProt IDQ9GZQ8
NCBI Gene ID81631
Ensembl IDENSG00000140941
OMIM609605
GeneCardsMAP1LC3B
Human Protein AtlasMAP1LC3B
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsrapamycin, cocaine, LPS
InteractionsGBA, FUNDC1, AMBRA1, PINK1, BCL2L13, NLRP3
KG Connections1993 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
APOE-Dependent Autophagy Restoration
Score: 0.61
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (11)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
AIF1 Gene
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

MAP1LC3B associated_with PINK1
MAP1LC3B associated_with PTEN
MAP1LC3B activates MYC
MAP1LC3B activates PIK3C3
MAP1LC3B activates PPARA
MAP1LC3B activates PPARG
MAP1LC3B activates PPARGC1A
MAP1LC3B activates RPS6
MAP1LC3B activates RPS6KB1
MAP1LC3B activates RUBCN