gene 753 words KG: GAPDH
Contents

GAPDH Gene

🧬 Gene Info
Gene SymbolGAPDH
Full NameGlyceraldehyde-3-Phosphate Dehydrogenase
Chromosome12p13.31
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight37 kDa
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Chaperone
UniProt IDP04406
NCBI Gene ID2597
Ensembl IDENSG00000111640
OMIM138400
GeneCardsGAPDH
Human Protein AtlasGAPDH
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds5-HT, dimethyl fumarate, levodopa, rapamycin, RAPAMYCIN, Vitamin C
InteractionsABP, ACAT1, ACTB, ACTG1, AGING, AIF1
KG Connections1389 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (35)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
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Related Analyses (14)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (2)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · completed · Score: 0.40
FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio
validation · proposed · Score: 0.40

See Also (5)

ACTB Gene
gene · KG edge: associated_with
ACTG1 Gene
gene · KG edge: interacts_with
AIF1 Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

STIP1 associated_with GAPDH
LGALS3 associated_with GAPDH
HSPA8 associated_with GAPDH
MCOLN1 associated_with GAPDH
SQSTM1 associated_with GAPDH
SOD1 associated_with GAPDH
BCL2 associated_with GAPDH
CTSB associated_with GAPDH
TPP1 associated_with GAPDH
GLA associated_with GAPDH

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