protein 1,949 words KG: LGALS3PROTEIN
Contents

LGALS3PROTEIN Protein

🔬 Protein Info
Gene SymbolLGALS3
Full NameGalectin-3 (LGALS3)
Chromosome14
Protein FamilyGalectin family (beta-galactoside-binding lectins)
FunctionLectin, cell adhesion, immune regulation, autophagy
Primary Expressionactivated microglia and plays complex roles in neuroinflammation - both promoting and resolving inflammatory responses
Molecular Weight29.8 kDa
PathwaysAmyloid, Lipid Metabolism
UniProt IDP17931
Ensembl IDENSG00000131981
OMIM153619
GeneCardsLGALS3
Human Protein AtlasLGALS3
LocationChromosome 14q22.3
Associated DiseasesAD, ALI, ALS, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsrapamycin
InteractionsCALCOCO2, G3BP1, PEX3, SQSTM1, BCL2, LMNA
KG Connections952 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (22)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in