| Gene Symbol | MCL1 |
| Full Name | Myeloid Cell Leukemia 1 |
| Aliases | MCL1PROTEIN |
| Chromosome | 1q21.2 |
| Function | encodes a critical anti-apoptotic protein of the BCL2 family that plays essential roles in regulating mitochondrial outer membrane permeabilization (MOMP), cellular survival, and mitochondrial dyna... |
| Subcellular Localization | </strong></td><td>Mitochondria, ER</td></tr> |
| Molecular Weight | 37 kDa |
| Amino Acids | 350 aa |
| Pathways | NF-κB |
| UniProt ID | [Q07820](https://www.uniprot.org/uniprot/Q07820) |
| Ensembl ID | ENSG00000143384 |
| GeneCards | MCL1 |
| Human Protein Atlas | MCL1 |
| BH1, BH2, BH3, BH4 Domains | Characteristic of anti-apoptotic BCL2 proteins |
| N-terminal PEST Sequences | Multiple PEST regions (rich in Proline, Glutamate, Serine, Threonine) target MCL1 for rapid ubiquitin-dependent degradation |
| Associated Diseases | AD, ALI, Als, Alzheimer, AMI |
| Interactions | ACHE, AD, APOB, APOE, APOPTOSIS, App |
| KG Connections | 345 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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