gene

APOB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections

0Hypotheses

0Analyses

50Outgoing

40Incoming

Summary

APOB is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, associated with. Associated with AD, ADH, ALI. Connected to 112 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	APOB
Full Name	Apolipoprotein B
Chromosome	Chr2p24.1
Function	The APOB gene encodes Apolipoprotein B, the main structural protein of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) particles.
Pathways	Cholesterol, Dna Methylation, Wnt
UniProt ID	P04114
NCBI Gene ID	338
Ensembl ID	ENSG00000184677
OMIM	107730
GeneCards	APOB
Human Protein Atlas	APOB
APOB-100	Full-length protein synthesized in liver, found on VLDL/LDL
APOB-48	Truncated form from intestinal mRNA, found on chylomicrons
N-terminal region	Lipid-binding beta-sheet structure (LDLR binding)
Central region	Large beta-sheet domains
Associated Diseases	AD, ADH, ALI, AMI, Als, Cancer
Interactions	MET, TERT, IDH1, SMARCA4, JUN, MDM4
KG Connections	156 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: APOB — AlphaFold P04114 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    APOB["APOB"] -->|"causes"| ADH["ADH"]
    APOB["APOB"] -->|"therapeutic target"| Cancer["Cancer"]
    APOB["APOB"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    APOB["APOB"] -->|"therapeutic target"| Ms["Ms"]
    APOB["APOB"] -->|"therapeutic target"| Als["Als"]
    APOB["APOB"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
    IDH1["IDH1"] -->|"therapeutic target"| APOB["APOB"]
    VEGFA["VEGFA"] -->|"therapeutic target"| APOB["APOB"]
    MDM4["MDM4"] -->|"therapeutic target"| APOB["APOB"]
    SF3B1["SF3B1"] -->|"therapeutic target"| APOB["APOB"]
    style APOB fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (116)

Target	Relation	Type	Str
Microglia	binds	cell_type	0.93
Autosomal Dominant Hypercholesterolemia	risk_factor_for	disease	0.90
Alzheimer's Disease	contributes_to	disease	0.90
ADH	causes	disease	0.72
Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Cardiac	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	contributes_to	disease	0.65
Metabolic Syndrome	contributes_to	disease	0.65
Cardiovascular	contributes_to	disease	0.65
Atherosclerosis	contributes_to	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Nafld	causes	disease	0.65
Fatty Liver	therapeutic_target	disease	0.65
Hypertension	expressed_in	disease	0.65
SF3B1	therapeutic_target	gene	0.60
MET	inhibits	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
MCL1	therapeutic_target	gene	0.60
LDLR	expressed_in	gene	0.60
MDM4	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
EEF1A1	associated_with	gene	0.60
IDH1	associated_with	gene	0.60
MCL1	associated_with	gene	0.60
MDM4	associated_with	gene	0.60
SF3B1	associated_with	gene	0.60
SMARCA4	associated_with	gene	0.60
TERT	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
TERT	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60

Incoming (40)

Source	Relation	Type	Str
IDH1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
SF3B1	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
CCS	associated_with	gene	0.60
APOE	regulates	gene	0.60
LDLR	regulates	gene	0.60
LRP6	contributes_to	gene	0.60
ABCB1	regulates	gene	0.60
EEF1A1	inhibits	gene	0.60
MDM4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
SF3B1	inhibits	gene	0.60
LDLR	expressed_in	gene	0.60
MCL1	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
IL-6	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
DNA	inhibits	gene	0.60
GENES	inhibits	gene	0.60
P53	inhibits	gene	0.60
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
LZTR1	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
LZTR1	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
PCSK9	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

APOB

Understanding Entity Pages

Summary

Wiki Pages (21)

APOB Gene

blood-brain-barrier-endothelial-cells

Wave Life Sciences

eef1a1

SF3B1

Wnt Signaling Dysfunction in Neurodegenerative Diseases

LRP2 — Low Density Lipoprotein Receptor-Related Protein 2 (Megalin)

LDL Receptor Protein

DNA Methylation

RARB

Wnt Signaling Modulation Therapy

Wnt Signaling Therapeutics: Investment Landscape Analysis

SORT1 Gene

APOA1 Gene

VEGFA — Vascular Endothelial Growth Factor A

Wnt Pathway Modulation for Synaptic Resilience

WNT Signaling in Neurodegeneration

APOB Protein

SCARB1 Protein (Scavenger Receptor Class B Type 1)