protein 939 words KG: METALLOTHIONEINS 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Metallothioneins

🔬 Protein Info
Gene SymbolMETALLOTHIONEINS
Full NameMetallothioneins
Protein TypeProtein
FunctionMetallothioneins (MTs) are a family of small, cysteine-rich that play crucial roles in metal homeostasis, antioxidant defense, and neuroprotection in the central nervous system
Primary Expressionastrocytes - Highly inducible by cytokines, metals, and oxidative stress - Critical for metal detoxification and astrocyte-neuron communication - Upre
Amino Acids68 aa
UniProt IDSearch UniProt
GeneCardsMETALLOTHIONEINS
Human Protein AtlasMETALLOTHIONEINS
Associated DiseasesALS, Huntington, Neurodegeneration
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (3)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40

See Also (10)

huntington-disease-treatment
therapeutic · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
HTT (Huntingtin)
gene · KG edge: associated_with
CD44 - Cell Surface Glycoprotein
gene · KG edge: associated_with
Genes
index · KG edge: associated_with

Knowledge Graph (12 edges)

METALLOTHIONEINS associated_with HUNTINGTON'S DISEASE
METALLOTHIONEINS associated_with HUNTINGTON
METALLOTHIONEINS associated_with AND
METALLOTHIONEINS associated_with ASTROCYTES
METALLOTHIONEINS associated_with Neurodegeneration
METALLOTHIONEINS associated_with Huntington
METALLOTHIONEINS associated_with ALS
METALLOTHIONEINS associated_with Lipid Metabolism
METALLOTHIONEINS expressed_in Astrocyte
METALLOTHIONEINS expressed_in Neuron