| Gene Symbol | METALLOTHIONEINS |
| Protein Type | Protein |
| Function | Metallothioneins (MTs) are a family of small, cysteine-rich that play crucial roles in metal homeostasis, antioxidant defense, and neuroprotection in the central nervous system |
| Primary Expression | astrocytes - Highly inducible by cytokines, metals, and oxidative stress - Critical for metal detoxification and astrocyte-neuron communication - Upre |
| Amino Acids | 68 aa |
| UniProt ID | Search UniProt |
| GeneCards | METALLOTHIONEINS |
| Human Protein Atlas | METALLOTHIONEINS |
| Cysteine-rich composition | 20 conserved cysteine residues (30% of total amino acids) |
| Metal-thiolate clusters | Zn(II)-thiolate clusters (Zn₇MT) that serve as zinc buffers |
| Metal-binding versatility | Can bind Zn²⁺, Cu⁺, Cd²⁺, Hg²⁺, and Fe²⁺ |
| Reduced domain organization | Two domains (β and α) with distinct metal-binding properties |
| Associated Diseases | ALS, Huntington, Neurodegeneration |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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