gene 3,036 words KG: HTT
Contents

HTT (Huntingtin)

🧬 Gene Info
Gene SymbolHTT
Full NameHuntingtin
Chromosome4p16.3.
Functionis a large, multifunctional protein encoded by the HTT gene on chromosome 4p16.
Subcellular Localizationand protein interactions
Molecular Weight350 kDa
Amino Acids144 aa
Exons67
PathwaysAutophagy, Dna Repair
UniProt IDP42857
NCBI Gene ID3064
Ensembl IDENSG00000197393
OMIM143100
GeneCardsHTT
Human Protein AtlasHTT
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, dimethyl fumarate, rapamycin
InteractionsP62, SQSTM1, TFEB, ULK1, MTOR, NFL
KG Connections745 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (23)

Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.63

Related Analyses (7)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic
validation · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40

See Also (5)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: co_discussed
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

HTT co_discussed LC3
HTT co_discussed MTOR
HTT activates HUNTINGTIN
HTT activates P62
HTT activates SETX
HTT activates SMN1
HTT activates SQSTM1
HTT activates TFEB
HTT activates ULK1
HTT activates WIPI2