protein 2,636 words KG: NFLPROTEIN
Contents

Neurofilament Light Chain (NFL)

🔬 Protein Info
Gene SymbolNEFL
Full NameNeurofilament Light Polypeptide
Chromosome8p21.2
Protein FamilyIntermediate filament family
Functionis a neuronal intermediate filament protein encoded by the NEFL gene on chromosome 8p21.
Primary ExpressionCNS and PNS neurons (axons)
Molecular Weight~61.5 kDa
Amino Acids543 aa
Exons4
PathwaysAmyloid, ubiquitin-proteasome
UniProt IDP07196
NCBI Gene ID4747
Ensembl IDENSG00000104825
OMIM162280
GeneCardsNEFL
Human Protein AtlasNEFL
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections275 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (43)

Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
← Prevpg 3/3

Related Analyses (21)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (6)

GWAS of plasma NfL in East Asian cohort
exploratory · proposed · Score: 0.95
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40
Environmental Exposure Causal Attribution in ALS — Experimen
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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