protein 2,636 words KG: NFLPROTEIN
Contents

Neurofilament Light Chain (NFL)

🔬 Protein Info
Gene SymbolNEFL
Full NameNeurofilament Light Polypeptide
Chromosome8p21.2
Protein FamilyIntermediate filament family
Functionis a neuronal intermediate filament protein encoded by the NEFL gene on chromosome 8p21.
Primary ExpressionCNS and PNS neurons (axons)
Molecular Weight~61.5 kDa
Amino Acids543 aa
Exons4
PathwaysAmyloid, ubiquitin-proteasome
UniProt IDP07196
NCBI Gene ID4747
Ensembl IDENSG00000104825
OMIM162280
GeneCardsNEFL
Human Protein AtlasNEFL
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections275 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (43)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Netrin-1 Gradient Restoration
Score: 0.59
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Cryptic Exon Silencing Restoration
Score: 0.53
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
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Related Analyses (21)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (6)

GWAS of plasma NfL in East Asian cohort
exploratory · proposed · Score: 0.95
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40
Environmental Exposure Causal Attribution in ALS — Experimen
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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