| Gene Symbol | NR4A1PROTEIN |
| Chromosome | 12p13.31 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 64 kDa |
| Amino Acids | 598 aa |
| Exons | 7 |
| GeneCards | NR4A1PROTEIN |
| Human Protein Atlas | NR4A1PROTEIN |
| DNA Binding | Binds to Nur response elements (NurRE) and NGFI-B response elements (NBRE) |
| Target Genes | Regulates genes involved in: |
| Coactivator Recruitment | Utilises p300/CBP for transcriptional activation |
| Calcium signaling | CaMK and calcineurin pathways |
| cAMP/PKA | Protein kinase A activation |
| MAPK cascades | ERK, JNK, and p38 pathways |
| Associated Diseases | Aging, Als, Inflammation, Ms, Neurodegeneration |
| Interactions | AKT, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, App, ARC |
| KG Connections | 125 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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