brain_region

ARC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

248Connections

30Hypotheses

8Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔮 Predicted Structure: ARC — AlphaFold Q7Z594 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARC["ARC"] -->|"regulates"| Aging["Aging"]
    ARC["ARC"] -->|"produces"| NPY["NPY"]
    ARC["ARC"] -->|"produces"| AGRP["AGRP"]
    ARC["ARC"] -->|"produces"| POMC["POMC"]
    ARC["ARC"] -->|"therapeutic target"| Oxidative_Stress["Oxidative Stress"]
    ARC["ARC"] -->|"regulates"| SYNAPSE["SYNAPSE"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| ARC["ARC"]
    FOS["FOS"] -->|"activates"| ARC["ARC"]
    STAT3["STAT3"] -->|"activates"| ARC["ARC"]
    BDNF["BDNF"] -->|"activates"| ARC["ARC"]
    style ARC fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (175)

Target	Relation	Type	Str
BDNF	activates	gene	0.75
neurotrophin signaling	participates_in	pathway	0.75
FOS	activates	gene	0.75
Aging	regulates	disease	0.75
synaptic plasticity	participates_in	pathway	0.75
NPY	produces	protein	0.72
AGRP	produces	protein	0.72
POMC	produces	protein	0.72
Oxidative Stress	therapeutic_target	pathway	0.70
SYNAPSE	regulates	gene	0.70
CREB1	activates	gene	0.65
Ms	regulates	disease	0.65
Als	associated_with	disease	0.65
Obesity	regulates	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
ALS	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Inflammation	activates	disease	0.65
Senescence	activates	disease	0.65
Obesity	activates	disease	0.65
Anxiety	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Retinopathy	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Glaucoma	associated_with	disease	0.65
Als	regulates	disease	0.65
Depression	regulates	disease	0.65
Hypertension	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Senescence	expressed_in	disease	0.65
Ferroptosis	inhibits	disease	0.65
Aging	contributes_to	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Als	degrades	disease	0.65
CREB	activates	gene	0.65
NPY	regulates	gene	0.60
CRH	regulates	gene	0.60
NTS	interacts_with	gene	0.60
FOXO3	therapeutic_target	gene	0.60
NESTIN	inhibits	gene	0.60
PIK3R3	activates	gene	0.60

Incoming (73)

Source	Relation	Type	Str
FOS	activates	gene	0.70
STAT3	activates	gene	0.70
BDNF	activates	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
CRH	regulates	gene	0.60
POMC	regulates	gene	0.60
NTS	interacts_with	gene	0.60
NESTIN	inhibits	gene	0.60
PIK3R3	activates	gene	0.60
AKT	regulates	gene	0.60
PI3K	interacts_with	gene	0.60
NPY	regulates	gene	0.60
FOXO3	therapeutic_target	gene	0.60
NR4A1	activates	gene	0.60
JUN	activates	gene	0.60
FOS	regulates	gene	0.60
PLIN2	activates	gene	0.60
MMP2	activates	gene	0.60
SIRT1	therapeutic_target	gene	0.60
PKC	regulates	gene	0.60
CALCINEURIN	regulates	gene	0.60
SNAP25	regulates	gene	0.60
GEPHYRIN	regulates	gene	0.60
C1Q	regulates	gene	0.60
CD8	activates	gene	0.60
CD4	activates	gene	0.60
AKT	activates	gene	0.60
NRF2	activates	gene	0.60
IFNG	activates	gene	0.60
AKT	associated_with	gene	0.60
AIF1	activates	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AMPK	therapeutic_target	gene	0.60
CREB	activates	gene	0.60
C-JUN	activates	gene	0.60
ERK	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
C-FOS	activates	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
C-FOS	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
GENES	regulates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-

[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-
[Archived Hypothesis]	0.000	-	-

Mentioning Analyses (8)

Scientific analyses that reference this entity

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.596

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

neurodegeneration | 2026-04-12 | 3 hypotheses Top: 0.700

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

neurodegeneration | 2026-04-11 | 0 hypotheses

Which specific aging-related gene expression changes in mouse brain predict huma

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ARC

Understanding Entity Pages

Wiki Pages (21)

Kisspeptin Neurons (Expanded)

Progressive Supranuclear Palsy (PSP)

Atypical Parkinsonism

NTF4 Protein

HNRNPA2B1 Protein

Epigenetic Dysregulation in Neurodegeneration

Pathway Diagram

Outgoing (175)

Incoming (73)

Targeting Hypotheses (30)

Mentioning Analyses (8)

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

Which specific aging-related gene expression changes in mouse brain predict huma

How can circuit-level neurodegeneration mechanisms be identified without complet

Which specific post-translational modifications distinguish pathological from ph

Which tau propagation mechanism predominates in different brain regions and dise

Related Papers (0)

ARC

Understanding Entity Pages

Wiki Pages (21)

Kisspeptin Neurons (Expanded)

Progressive Supranuclear Palsy (PSP)

Atypical Parkinsonism

NTF4 Protein

HNRNPA2B1 Protein

Epigenetic Dysregulation in Neurodegeneration

CREB Signaling in Neurodegeneration

Angelman Syndrome

Notch Signaling Pathway in Neurodegeneration

Synaptic Plasticity Deficits in Neurodegeneration

Vestibular Function Testing in Corticobasal Syndrome

Retromer Dysfunction in Corticobasal Syndrome

Amyloid Precursor Protein (APP)

Longevity and Rejuvenation Therapies Landscape

Epigenetic Mechanisms in Alzheimer's Disease

Oxytocin Receptor Neurons

Tanycytes

Arcuate Nucleus POMC Neurons

Neuropeptide Y (NPY) Neurons

Section 240: Advanced Narrative Therapy and Life Review in CBS/PSP

Manganese-Related Neurodegeneration (Manganism)

Pathway Diagram

Outgoing (175)

Incoming (73)

Targeting Hypotheses (30)

Mentioning Analyses (8)

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

Which specific aging-related gene expression changes in mouse brain predict huma

How can circuit-level neurodegeneration mechanisms be identified without complet

Which specific post-translational modifications distinguish pathological from ph

Which tau propagation mechanism predominates in different brain regions and dise

Related Papers (0)