| Gene Symbol | OPA1 |
| Full Name | Optic Atrophy 1 |
| Aliases | OPA1PROTEIN |
| Chromosome | 3q29 |
| Protein Family | Dynamin GTPase family |
| Protein Type | Protein |
| Function | OPA1 is a nuclear-encoded mitochondrial protein that functions as a large GTPase mediating mitochondrial inner membrane fusion. |
| Subcellular Localization | Mitochondrial inner membrane |
| Molecular Weight | ~100 kDa (isoforms 83-100 kDa) |
| Amino Acids | 300 aa |
| Pathways | Apoptosis, Lysosomal Degradation, Mitochondrial Function, Mitophagy, Mtor |
| UniProt ID | O60393 |
| NCBI Gene ID | 4976 |
| GeneCards | OPA1 |
| Human Protein Atlas | OPA1 |
| Associated Diseases | ALS, Aging, Alzheimer, CHARCOT-MARIE-TOOTH, Cancer |
| Interactions | MFN1, AKT, VDAC1, MFN2, FOXO3, MLKL |
| KG Connections | 793 knowledge graph edges |
| Databases | GeneCardsHPASTRING |