| Gene Symbol | PLD3 |
| Full Name | Phospholipase D3 |
| Chromosome | 19q13.32 |
| Protein Type | Enzyme |
| Function | is an endoplasmic reticulum-resident phospholipase enzyme that plays critical roles in cellular lipid metabolism and lysosomal function. |
| Primary Expression | brain regions vulnerable to neurodegeneration, and its expression is reduced in Alzheimer's disease brains |
| Subcellular Localization | </b></td><td>Endoplasmic reticulum, Lysosomes</td></tr> |
| Amino Acids | 473 aa |
| Pathways | APP metabolism, Autophagy, Cholesterol, Mitophagy, nucleotide signaling |
| UniProt ID | Q8N8S7 |
| NCBI Gene ID | 23646 |
| Ensembl ID | ENSG00000119608 |
| OMIM | 614739 |
| GeneCards | PLD3 |
| Human Protein Atlas | PLD3 |
| Associated Diseases | Alzheimer, Alzheimer's disease, Ms |
| Interactions | CGAS, STING, APP, TREM2, SREBF2, YY1 |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsHPASTRING |