protein 543 words KG: RECQL4 2026-03-14
kind:proteinsection:proteinsstate:published
Contents

RECQL4 Protein

🔬 Protein Info
Gene SymbolRECQL4
Full NameRECQ DNA Helicase Like 4
Chromosome8q24.3
Protein FamilyRecQ DNA Helicase Family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionSkeletal muscle, Bone marrow, Brain (cerebellum, cortex)
Subcellular LocalizationNucleus, Mitochondria
Molecular Weight120 kDa
PathwaysNf-Κb
UniProt IDQ9U143
Ensembl IDENSG00000015171
GeneCardsRECQL4
Human Protein AtlasRECQL4
GeneRECQL4
PDB Structures2V6A, 2JGF
Associated DiseasesTumor
InteractionsYBX1, NF-ΚB, GAIN, G3BP1, GENES
KG Connections10 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Phase-Separated Organelle Targeting
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (7)

YBX1 Gene
gene · KG edge: activates
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: activates
G3BP1
gene · KG edge: activates
Genes
index · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with

Knowledge Graph (10 edges)

RECQL4 activates YBX1
RECQL4 activates Carcinoma
RECQL4 associated_with Tumor
RECQL4 activates Ms
RECQL4 activates Nf-Κb
RECQL4 activates NF-ΚB
GAIN activates RECQL4
G3BP1 activates RECQL4
GENES activates RECQL4
DNA associated_with RECQL4