protein 543 words KG: RECQL4
Contents

RECQL4 Protein

🔬 Protein Info
Gene SymbolRECQL4
Full NameRECQ DNA Helicase Like 4
Chromosome8q24.3
Protein FamilyRecQ DNA Helicase Family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionSkeletal muscle, Bone marrow, Brain (cerebellum, cortex)
Subcellular LocalizationNucleus, Mitochondria
Molecular Weight120 kDa
PathwaysNf-Κb
UniProt IDQ9U143
Ensembl IDENSG00000015171
GeneCardsRECQL4
Human Protein AtlasRECQL4
N-terminal RegionContains the "RecQ helicase" domain with conserved helicase motifs (I-VI)
C-terminal RegionContains a Sld2-like domain required for DNA binding
Associated DiseasesTumor
InteractionsG3BP1, GAIN, GENES, NF-ΚB, YBX1
KG Connections10 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (6)

Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
RNA Granule Nucleation Site Modulation
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Genes
index · KG edge: activates
G3BP1
gene · KG edge: activates

Knowledge Graph (10 edges)

GAIN activates RECQL4
G3BP1 activates RECQL4
RECQL4 activates YBX1
GENES activates RECQL4
DNA associated_with RECQL4
RECQL4 activates Carcinoma
RECQL4 associated_with Tumor
RECQL4 activates Ms
RECQL4 activates Nf-Κb
RECQL4 activates NF-ΚB

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.