| Gene Symbol | RELAPROTEIN |
| Full Name | RELA (p65) |
| Protein Type | Protein |
| Function | is a major driver of neuroinflammation, a hallmark pathological feature of Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). |
| Primary Expression | neurons, astrocytes, microglia, and oligodendrocytes, where it |
| Amino Acids | 300 aa |
| UniProt ID | Search UniProt |
| GeneCards | RELAPROTEIN |
| Human Protein Atlas | RELAPROTEIN |
| Rel Homology Domain (RHD) | The N-terminal ~300 amino acids comprise the RHD, which mediates DNA binding, dimerization, and interaction with IκB inhibitors |
| Transactivation Domain (TAD) | The C-terminal region contains two TADs (TAD1 and TAD2) that recruit transcriptional coactivators including CBP/p300 |
| RHD | Enables dimerization with p50, p52, c-Rel, or RELB to form functional NF-κB dimers |
| Inflammatory mediators | TNF-α, IL-1β, IL-6, COX-2, iNOS |
| Anti-apoptotic proteins | Bcl-2, Bcl-xL, c-IAP1/2, XIAP |
| Acute phase proteins | CRP, serum amyloid A |
| Associated Diseases | Aging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation |
| Known Drugs/Compounds | RESVERATROL |
| Interactions | AKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND |
| KG Connections | 750 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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