protein 1,247 words KG: SIRT5PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

SIRT5 Protein - Mitochondrial Desuccinylase

🔬 Protein Info
Gene SymbolSIRT5
Full NameSirtuin 5
AliasesPage for SIRT5 Protein
Chromosome6p23
Protein FamilySirtuin family (class I)
Functionis a member of the sirtuin family of NAD⁺-dependent protein deacylases that is primarily localized to mitochondria.
Molecular Weight~34 kDa (full-length)
Amino Acids310 aa
PathwaysGlutamine Metabolism, Glycolysis, Mitophagy, Oxidative Stress, Unfolded Protein Response
UniProt IDQ9NXE1
NCBI Gene ID25998
Ensembl IDENSG00000124562
OMIM604603
GeneCardsSIRT5
Human Protein AtlasSIRT5
Associated DiseasesALS, Alzheimer, cancer
Known Drugs/CompoundsMc3482, MC3482
InteractionsBNIP3, PINK1, PARK2, MAP1LC3B, GABARAPL2, EP300
KG Connections219 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.40
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (14)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Sirtuin Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in