protein

AKT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AKT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

16Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	AKT2
Full Name	AKT Serine/Threonine Kinase 2
Chromosome	19q13.2
Protein Type	Kinase
Function	is a crucial signaling molecule in the PI3K/AKT signaling pathway that plays essential roles in cell survival, metabolism, and neuronal function.
Primary Expression	Brain (widespread), Muscle, Liver, Adipose tissue
Exons	13
Pathways	Akt, Apoptosis, Autophagy, Immune Response, Mitophagy
UniProt ID	P31751
NCBI Gene ID	207
Ensembl ID	ENSG00000105221
OMIM	164731
GeneCards	AKT2
Human Protein Atlas	AKT2
Associated Diseases	ALS, Aging, Atherosclerosis, Cancer, Cardiovascular
Interactions	TFE3, TFEB, UBIQUITIN, PI3K, APP, VEGF
KG Connections	101 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AKT2 — AlphaFold P31751 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AKT2["AKT2"] -->|"modulates"| Lysosomal_Synapse_Formation["Lysosomal Synapse Formation"]
    style Lysosomal_Synapse_Formation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"modulates"| Lysosomal_Synapses["Lysosomal Synapses"]
    style Lysosomal_Synapses fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"regulates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"regulates"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"associated"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"implicated in"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"implicated in"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT3["AKT3"] -->|"associated"| AKT2["AKT2"]
    style AKT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AKT["AKT"] -->|"associated"| AKT2["AKT2"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"regulates"| AKT2["AKT2"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"regulates"| AKT2["AKT2"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MIRNAS["MIRNAS"] -->|"regulates"| AKT2["AKT2"]
    style MIRNAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style AKT2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (85)

Target	Relation	Type	Str
Lysosomal Synapse Formation	modulates	process	0.95
Glucose Metabolism	regulates	process	0.90
glucose uptake	promotes	process	0.88
Lysosomal Synapses	modulates	process	0.85
Hepatic Glycogen Synthesis	involved_in	process	0.85
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Aging	associated_with	disease	0.65
Cancer	implicated_in	disease	0.65
Atherosclerosis	implicated_in	disease	0.65
Cardiovascular	implicated_in	disease	0.65
Als	implicated_in	disease	0.65
Alzheimer	activates	disease	0.65
Diabetes	activates	disease	0.65
AKT1	associated_with	gene	0.60
TFE3	activates	gene	0.60
SIRT5	therapeutic_target	gene	0.60
TFEB	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
MUL1	regulates	gene	0.60
AKT	associated_with	gene	0.60
OVERVIEW	implicated_in	gene	0.60
AKT3	associated_with	gene	0.60
PI3K	inhibits	gene	0.60
AKT	implicated_in	gene	0.60
AKT3	implicated_in	gene	0.60
APP	activates	gene	0.60
CD36	regulates	gene	0.60
FAS	regulates	gene	0.60
FOXO1	regulates	gene	0.60
IRS2	regulates	gene	0.60
VEGF	activates	gene	0.60
VEGF	regulates	gene	0.60
LC3	activates	gene	0.60
VEGF	inhibits	gene	0.60
VEGF	associated_with	gene	0.60
SIRT5	inhibits	gene	0.60
SIRT5	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
SIRT5	activates	gene	0.60
CFH	activates	gene	0.60
SIRT5	targets	gene	0.60
TFEB	targets	gene	0.60
Autophagy	regulates	pathway	0.60
Akt	associated_with	pathway	0.60
Pi3K	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Phagocytosis	regulates	pathway	0.60
COMPLEMENT	activates	gene	0.60

Incoming (16)

Source	Relation	Type	Str
IRS2	activates	gene	0.90
AKT3	associated_with	gene	0.60
AKT	associated_with	gene	0.60
PI3K	regulates	gene	0.60
MTOR	regulates	gene	0.60
CFH	activates	gene	0.60
AKT1	associated_with	gene	0.60
AKT1	implicated_in	gene	0.60
APP	activates	gene	0.60
MIRNAS	regulates	gene	0.60
AGING	associated_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AKT2

Understanding Entity Pages

Wiki Pages (19)

AKT2 Gene

PDPK1 Gene

pi3k-akt-signaling

DJ-1-PTEN-P53 Network

Akt Signaling Pathway in Neurodegeneration

PI3K/Akt Signaling in Neurodegeneration

PI3K-Akt Signaling in Parkinson's Disease

PI3K/Akt Signaling in Parkinson's Disease

AKT1 Protein

AKT (Protein Kinase B) Neurons

AKT1 Protein (Protein Kinase B Alpha)

AKT1 Gene

akt-protein

CFH

AKT3 Gene

AKT3 Protein

AKT2 Protein