protein 803 words KG: SLC6A4PROTEIN 2026-03-17
kind:proteinsection:proteinsstate:published
Contents

slc6a4 Protein

🔬 Protein Info
Gene SymbolSLC6A4 (SERT, 5HTT)
AliasesSerotonin Transporter
Chromosome17q11.2
Functionis a membrane protein that mediates the reuptake of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft back into presynaptic neurons.
Subcellular Localization</b></td><td>Plasma membrane, presynaptic terminal</td></tr>
Molecular Weight63 kDa
Amino Acids630 aa
Exons14
PathwaysApoptosis, Epigenetic, Mapk, autophagy pathway
UniProt IDP31645
NCBI Gene ID6532
Ensembl IDENSG00000108576
Associated DiseasesALS, Addiction, Alzheimer, Alzheimer'S Disease
InteractionsJUN, CASP3, ERK2, RHOT1, STING, SYN1
KG Connections320 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses