protein 803 words KG: SLC6A4PROTEIN
Contents

slc6a4 Protein

🔬 Protein Info
Gene SymbolSLC6A4 (SERT, 5HTT)
AliasesSerotonin Transporter
Chromosome17q11.2
Functionis a membrane protein that mediates the reuptake of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft back into presynaptic neurons.
Subcellular Localization</b></td><td>Plasma membrane, presynaptic terminal</td></tr>
Molecular Weight63 kDa
Amino Acids630 aa
Exons14
PathwaysApoptosis, Epigenetic, Mapk, autophagy pathway
UniProt IDP31645
NCBI Gene ID6532
Ensembl IDENSG00000108576
Associated DiseasesAddiction, Als, Alzheimer, Alzheimer's disease
InteractionsActin, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, APOPTOSIS
KG Connections325 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
nct05508789
clinical_trial · Pages share 4 hypotheses
MK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

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