| Gene Symbol | SP1PROTEIN |
| Full Name | Sp1 |
| Protein Type | Protein |
| Function | is a zinc finger transcription factor that plays crucial roles in regulating gene expression in neuronal cells. |
| UniProt ID | Search UniProt |
| GeneCards | SP1PROTEIN |
| Human Protein Atlas | SP1PROTEIN |
| DNA-Binding Domain | Three C2H2-type zinc finger motifs at the C-terminus that recognize GC-box sequences (5'-GGGGCGG-3') |
| Transactivation Domain | Rich in glutamine at the N-terminus, responsible for recruiting transcriptional co-activators |
| Domain for Protein-Protein Interactions | Enables interaction with other transcription factors and co-factors |
| Direct Binding | Binds to GC-rich promoter elements to activate transcription |
| Chromatin Remodeling | Interacts with histone acetyltransferases (HATs) and histone deacetylases (HDACs) |
| Cooperative Binding | Multiple Sp1 molecules can bind cooperatively to enhance transcriptional activation |
| Post-Translational Modifications | Phosphorylation, acetylation, and sumoylation regulate its activity[@tan2009] |
| [BACE1](/entities/bace1) Expression | Modulates BACE1 (beta-secretase) transcription, the rate-limiting enzyme in amyloid-beta generation |
| Associated Diseases | Als, Alzheimer, Ms |
| Known Drugs/Compounds | Glucosamine |
| Interactions | APP, ATP2A3, CANCER, CHOP, DKK1, DNA |
| KG Connections | 156 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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