DKK1

Understanding Entity Pages

This page aggregates everything SciDEX knows about DKK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

DKK1 encodes a secreted Wnt pathway inhibitor with critical roles in development, bone homeostasis, and neurodegenerative diseases

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flowchart TD
    DKK1["DKK1"] -.->|"inhibits"| Wnt_signaling_pathway["Wnt signaling pathway"]
    ESRRA["ESRRA"] -->|"regulates"| DKK1["DKK1"]
    ESRRG["ESRRG"] -->|"regulates"| DKK1["DKK1"]
    DKK1["DKK1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    DKK1["DKK1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    DKK1["DKK1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    DKK1["DKK1"] -->|"therapeutic target"| Cancer["Cancer"]
    DKK1["DKK1"] -->|"therapeutic target"| Als["Als"]
    DKK1["DKK1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    DKK1["DKK1"] -->|"therapeutic target"| Ms["Ms"]
    DKK1["DKK1"] -->|"activates"| Carcinoma["Carcinoma"]
    DKK1["DKK1"] -->|"activates"| Cancer["Cancer"]
    style DKK1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Wnt_signaling_pathway fill:#1b5e20,stroke:#333,color:#e0e0e0
    style ESRRA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ESRRG fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0