gene

ATP2A3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP2A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections
0Hypotheses
0Analyses
24Outgoing
13Incoming

Summary

ATP2A3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with ALS, Als, Cancer. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolATP2A3
Full NameATP2A3
Chromosome7p13.
Protein TypeGene
Functionis a calcium pump encoded by the ATP2A3 gene located on chromosome 7p13.
Primary Expressiondopaminergic neurons; dysfunction contributes to their selective vulnerability[@zndorf2011]
Amino Acids1042 aa
PathwaysCalcium Homeostasis
NCBI Gene IDSearch NCBI
GeneCardsATP2A3
Human Protein AtlasATP2A3
Associated DiseasesALS, Colon Cancer, Gastric Cancer
InteractionsSP1, SP3, DNA, CANCER, AND, KLF4
KG Connections37 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

ATP2A3 Gene

gene · 750 words

Inferior Olivary Nucleus

cell · 1222 words

ATP2A1 Gene

gene · 657 words

SP1 (Specificity Protein 1)

gene · 647 words

ATP2A2 Protein (SERCA2)

protein · 629 words

HDAC Inhibitors

therapeutics · 619 words

Pathway Diagram

graph TD
    ATP2A3["<b>ATP2A3</b>"]
    Cancer{"Cancer"}
    ATP2A3 -->|"activates"| Cancer
    Ms{"Ms"}
    ATP2A3 -->|"activates"| Ms
    Als{"Als"}
    ATP2A3 -->|"activates"| Als
    ALS{"ALS"}
    ATP2A3 -->|"activates"| ALS
    SP1["SP1"]
    ATP2A3 -->|"interacts with"| SP1
    DNA["DNA"]
    ATP2A3 -->|"interacts with"| DNA
    SP3["SP3"]
    ATP2A3 -->|"interacts with"| SP3
    CANCER["CANCER"]
    ATP2A3 -->|"activates"| CANCER
    Ca3["Ca3"]
    ATP2A3 -->|"expressed in"| Ca3
    neurodegeneration["neurodegeneration"]
    ATP2A3 -->|"implicated in"| neurodegeneration
    SP1 -->|"interacts with"| ATP2A3
    SP3 -->|"interacts with"| ATP2A3
    DNA -->|"interacts with"| ATP2A3
    AND["AND"]
    AND -->|"activates"| ATP2A3
    style ATP2A3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

TargetRelationTypeStr
SERCA3encodesprotein1.00
Cell Differentiationupregulatesprocess0.93
Colon Cancerassociated_withdisease0.90
Gastric Cancerassociated_withdisease0.90
Calcium Homeostasisinvolved_inprocess0.85

Incoming (13)

SourceRelationTypeStr
Cell Differentiationupregulatesprocess1.00
SP1activatesgene0.95
SP3activatesgene0.95
KLF4activatesgene0.95
SP1bindsprotein0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found