Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP2A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ATP2A3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with ALS, Als, Cancer. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | ATP2A3 |
| Full Name | ATP2A3 |
| Chromosome | 7p13. |
| Protein Type | Gene |
| Function | is a calcium pump encoded by the ATP2A3 gene located on chromosome 7p13. |
| Primary Expression | dopaminergic neurons; dysfunction contributes to their selective vulnerability[@zndorf2011] |
| Amino Acids | 1042 aa |
| Pathways | Calcium Homeostasis |
| NCBI Gene ID | Search NCBI |
| GeneCards | ATP2A3 |
| Human Protein Atlas | ATP2A3 |
| Associated Diseases | ALS, Colon Cancer, Gastric Cancer |
| Interactions | SP1, SP3, DNA, CANCER, AND, KLF4 |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
ATP2A3["<b>ATP2A3</b>"]
Cancer{"Cancer"}
ATP2A3 -->|"activates"| Cancer
Ms{"Ms"}
ATP2A3 -->|"activates"| Ms
Als{"Als"}
ATP2A3 -->|"activates"| Als
ALS{"ALS"}
ATP2A3 -->|"activates"| ALS
SP1["SP1"]
ATP2A3 -->|"interacts with"| SP1
DNA["DNA"]
ATP2A3 -->|"interacts with"| DNA
SP3["SP3"]
ATP2A3 -->|"interacts with"| SP3
CANCER["CANCER"]
ATP2A3 -->|"activates"| CANCER
Ca3["Ca3"]
ATP2A3 -->|"expressed in"| Ca3
neurodegeneration["neurodegeneration"]
ATP2A3 -->|"implicated in"| neurodegeneration
SP1 -->|"interacts with"| ATP2A3
SP3 -->|"interacts with"| ATP2A3
DNA -->|"interacts with"| ATP2A3
AND["AND"]
AND -->|"activates"| ATP2A3
style ATP2A3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| SERCA3 | encodes | protein | 1.00 |
| Cell Differentiation | upregulates | process | 0.93 |
| Colon Cancer | associated_with | disease | 0.90 |
| Gastric Cancer | associated_with | disease | 0.90 |
| Calcium Homeostasis | involved_in | process | 0.85 |
| Cancer | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| SP1 | activates | entity | 0.60 |
| SP3 | activates | entity | 0.60 |
| CANCER | expressed_in | entity | 0.60 |
| SP1 | interacts_with | gene | 0.60 |
| SP3 | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| Epithelial | activates | cell_type | 0.60 |
| DNA | activates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Ca3 | expressed_in | brain_region | 0.55 |
| cancer | activates | disease | 0.50 |
| ENDOPLASMIC RETICULUM | activates | concept | 0.50 |
| GENE EXPRESSION | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Cell Differentiation | upregulates | process | 1.00 |
| SP1 | activates | gene | 0.95 |
| SP3 | activates | gene | 0.95 |
| KLF4 | activates | gene | 0.95 |
| SP1 | binds | protein | 0.95 |
| SP3 | binds | protein | 0.95 |
| KLF4 | binds | protein | 0.95 |
| HDAC Inhibitors | upregulates | drug | 0.88 |
| Histone Deacetylase Inhibitors | upregulates | drug | 0.85 |
| SP1 | interacts_with | gene | 0.60 |
| SP3 | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||