protein 878 words KG: SPI1PROTEIN
Contents

PU.1 Protein (SPI1)

🔬 Protein Info
Gene SymbolSPI1
Full NamePU.1 Transcription Factor / Spi-1 Proto-Oncogene
AliasesSPI1/PU.1
Chromosome19q13.3
Protein TypeTranscription Factor
Functionencodes a transcription factor of the E26 transformation-specific (ETS) family.
Subcellular Localization</b></td><td>Nucleus</td></tr>
Amino Acids270 aa
PathwaysAmyloid, Mtor, Pi3K/Akt
UniProt IDP17947
NCBI Gene ID6678
Ensembl IDENSG00000135336
OMIM165010
GeneCardsSPI1
Human Protein AtlasSPI1
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease
InteractionsActin, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
SciDEX HypothesesSPI1-C1Q Transcriptional Circuit Drives Cerebrovas
Neurovascular Unit SPI1 Signaling Hub
Epigenetic SPI1 Reprogramming Therapy (+3 more)
KG Connections434 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (21)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
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Related Analyses (8)

How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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