protein 878 words KG: SPI1PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PU.1 Protein (SPI1)

🔬 Protein Info
Gene SymbolSPI1
Full NamePU.1 Transcription Factor / Spi-1 Proto-Oncogene
AliasesSPI1/PU.1
Chromosome19q13.3
Protein TypeTranscription Factor
Functionencodes a transcription factor of the E26 transformation-specific (ETS) family.
Subcellular Localization</b></td><td>Nucleus</td></tr>
Amino Acids270 aa
PathwaysAmyloid, Mtor, Pi3K/Akt
UniProt IDP17947
NCBI Gene ID6678
Ensembl IDENSG00000135336
OMIM165010
GeneCardsSPI1
Human Protein AtlasSPI1
Associated DiseasesAD, ALI, ALS, Alzheimer, Alzheimer's disease
InteractionsTAU, HNF4A, AXIN1, TBP, YWHAZ, SOCS3
KG Connections439 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (21)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (8)

How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in