protein 1,058 words KG: SREBP1PROTEIN
Contents

SREBP1 Protein (Sterol Regulatory Element-Binding Protein 1)

🔬 Protein Info
Gene SymbolSREBP1
AliasesSterol Regulatory Element-Binding Protein 1
FunctionRegulatory Element-Binding Protein 1)
Molecular Weight125 kDa
Amino Acids480 aa
PathwaysFatty Acid Synthesis, Cholesterol Synthesis, Lipid Metabolism, Mtor, Cholesterol
GeneCardsSREBP1
Human Protein AtlasSREBP1
Associated DiseasesAls, cancer, Carcinoma, ferroptosis, Hepatocellular Carcinoma, Neurodegeneration
Known Drugs/CompoundsNobiletin, NOBILETIN, rapamycin
InteractionsACLY, AHR, AKT, AMPK, AMYLOID, AND
KG Connections212 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (15)

Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
APOE-Dependent Autophagy Restoration
Score: 0.89
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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