gene 889 words KG: SCN1A
kind:genesection:entitiesstate:publishedtopic:neurodevelopmental-epilepsy
Contents

SCN1A

🧬 Gene Info
Gene SymbolSCN1A
Chromosome2q24.3
Primary ExpressionBrain (neurons, particularly GABAergic interneurons), heart
Molecular Weight226 kDa
Amino Acids2000 aa
UniProt IDP35499
NCBI Gene ID6335
Ensembl IDENSG00000144285
OMIM182389
GeneCardsSCN1A
Human Protein AtlasSCN1A
Genomic Coordinateschr2:165,990,000-166,100,000 (GRCh38)
Gene Length~190 kb
Number of Exons26 coding exons
Transcript Length~7.2 kb coding sequence
Associated DiseasesAls, Cancer, Epilepsy
InteractionsSNAP25, PVALB, GENES
KG Connections171 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Extracellular Matrix Stiffness Modulation
Score: 0.43

Related Analyses (3)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: associated_with
DHX9 — DEAH-Box Helicase 9
gene · KG edge: therapeutic_target
CFTR Gene
gene · KG edge: associated_with
CACNA1C Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SCN1A associated_with TRPV4
SCN1A associated_with CACNA1B
SCN1A associated_with SCNN1A
SCN1A associated_with CFTR
SCN1A associated_with PIEZO2
SCN1A associated_with TRPA1
SCN1A associated_with KCNMA1
SCN1A associated_with TRPV1
SCN1A associated_with KCNN4
SCN1A associated_with KCNQ1