protein

HSC70

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSC70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for Hsc70 Protein

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🔬 Protein Info

Gene Symbol	HSC70
Molecular Weight	71 kDa
Pathways	Chaperone
GeneCards	HSC70
Human Protein Atlas	HSC70
Associated Diseases	ALS, Alzheimer, Parkinson's disease, dementia, frontotemporal, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	HSP110, HSP40, HSP70, HSPA1A, HSPA8, HSPH1
KG Connections	147 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HSC70["<b>HSC70</b>"]
    PDI["PDI"]
    PDI -->|"interacts with"| HSC70
    PKM2["PKM2"]
    HSC70 -->|"activates"| PKM2
    VPS34["VPS34"]
    HSC70 -->|"activates"| VPS34
    KAT2B["KAT2B"]
    HSC70 -->|"activates"| KAT2B
    TUMOR["TUMOR"]
    HSC70 -->|"activates"| TUMOR
    PARKINSON["PARKINSON"]
    HSC70 -->|"activates"| PARKINSON
    apoptosis["apoptosis"]
    HSC70 -->|"activates"| apoptosis
    AMPK["AMPK"]
    HSC70 -->|"activates"| AMPK
    MAP1LC3["MAP1LC3"]
    HSC70 -->|"activates"| MAP1LC3
    CELL_CYCLE["CELL CYCLE"]
    HSC70 -->|"activates"| CELL_CYCLE
    ACETYL_COA["ACETYL-COA"]
    HSC70 -->|"activates"| ACETYL_COA
    ACAT1["ACAT1"]
    HSC70 -->|"activates"| ACAT1
    Chaperone["Chaperone"]
    HSC70 -->|"activates"| Chaperone
    disease["disease"]
    HSC70 -->|"activates"| disease
    Proteins["Proteins"]
    HSC70 -->|"activates"| Proteins
    GSK3["GSK3"]
    HSC70 -->|"activates"| GSK3
    RAPAMYCIN["RAPAMYCIN"]
    HSC70 -->|"activates"| RAPAMYCIN
    CHAPERONE_MEDIATED_AUTOPHAGY["CHAPERONE-MEDIATED AUTOPHAGY"]
    HSC70 -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY
    AUTOPHAGOSOME["AUTOPHAGOSOME"]
    HSC70 -->|"activates"| AUTOPHAGOSOME
    ferroptosis["ferroptosis"]
    HSC70 -->|"activates"| ferroptosis
    MUNC18_1["MUNC18-1"]
    HSC70 -->|"interacts with"| MUNC18_1
    Proteins["Proteins"]
    HSC70 -->|"interacts with"| Proteins
    TFEB["TFEB"]
    TFEB -->|"activates"| HSC70
    Autophagy["Autophagy"]
    Autophagy -->|"activates"| HSC70
    ULK1["ULK1"]
    ULK1 -->|"activates"| HSC70
    OPTN["OPTN"]
    OPTN -->|"activates"| HSC70
    NDP52["NDP52"]
    NDP52 -->|"activates"| HSC70
    FIP200["FIP200"]
    FIP200 -->|"activates"| HSC70
    BECN1["BECN1"]
    BECN1 -->|"activates"| HSC70
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"activates"| HSC70

Outgoing (84)

Target	Relation	Type	Str
GPX4	binds	gene	0.87
Α-SYNUCLEIN	interacts_with	protein	0.85
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
KAT2A	activates	gene	0.60
KAT5	activates	gene	0.60
KAT8	activates	gene	0.60
LAMP2A	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
PIK3C3	activates	gene	0.60
RB1	activates	gene	0.60
RB1CC1	activates	gene	0.60
RUBCN	activates	gene	0.60
RUBCNL	activates	gene	0.60
SIRT1	activates	gene	0.60
SNAP29	activates	gene	0.60
SNARE	activates	gene	0.60
SQSTM1	activates	gene	0.60
STX17	activates	gene	0.60
TFEB	activates	gene	0.60
TP53	activates	gene	0.60
ULK1	activates	gene	0.60
VAMP8	activates	gene	0.60
WIPI2	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
Wnt signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
HSP90AA1	implicated_in	gene	0.60
HSPA8	implicated_in	gene	0.60
LRP1	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
HSP70	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
HSPA8	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
STUB1	regulates	gene	0.60
VCP	regulates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
Parkinson's disease	associated_with	disease	0.60
neurons	expressed_in	cell_type	0.60
LAMP2A	interacts_with	gene	0.60

Incoming (63)

Source	Relation	Type	Str
VPS35	interacts_with	protein	0.90
PDI	interacts_with	protein	0.80
ACAT1	activates	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
CBP	activates	gene	0.60
GSK3	activates	gene	0.60
rapamycin	targets	drug	0.60
BAG3	regulates	gene	0.60
CALR	regulates	gene	0.60
GR	regulates	gene	0.60
CDK5	activates	gene	0.60
ATG5	inhibits	gene	0.60
ALDH1A1	implicated_in	gene	0.60
DNA	regulates	gene	0.60
DNAJC13	regulates	gene	0.60
DNAJA1	activates	gene	0.55
DNAJB1	activates	gene	0.55
TFEB	activates	protein	0.50
Autophagy	activates	process	0.50
ULK1	activates	gene	0.50
OPTN	activates	gene	0.50
NDP52	activates	gene	0.50
FIP200	activates	gene	0.50
BECN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
SNAP29	activates	gene	0.50
mTOR	activates	entity	0.50
WIPI2	activates	gene	0.50
PIK3C3	activates	gene	0.50
KAT8	activates	gene	0.50
GAPDH	activates	gene	0.50
TP53	activates	gene	0.50
SIRT1	activates	gene	0.50
RUBCN	activates	gene	0.50
HDAC6	activates	gene	0.50
CREBBP	activates	gene	0.50
EP300	activates	gene	0.50
LAMP2A	activates	gene	0.50
RB1CC1	activates	gene	0.50
KAT2A	activates	gene	0.50
KAT5	activates	gene	0.50
STX17	activates	gene	0.50
VAMP8	activates	gene	0.50
HSPA8	activates	gene	0.50
CALCOCO2	activates	gene	0.50
NBR1	activates	gene	0.50
CREB	activates	protein	0.50
SNARE	activates	protein	0.50
OPTINEURIN	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HSC70

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Synaptic Vesicle Trafficking in Parkinson's Disease

Gene-Mechanism-Therapy Causal Chains

Chaperone-Mediated Autophagy in Neurodegeneration

Lysosomal Dysfunction in Neurodegeneration

ubiquitin-proteasome-dysfunction-neurodegeneration

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

BAG5 Gene

Autophagy-Lysosomal Pathway in Parkinson's Disease

Heat Shock Protein Response Pathway in Neurodegeneration

autophagy-lysosome-dysfunction

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

Section 189: Advanced Autophagy-Endolysosomal Pathway Therapy in CBS/PSP

Synaptic Vesicle Cycle

Chaperone-Mediated Autophagy in Neurodegeneration

Synaptic Vesicle Trafficking

Protein Quality Control in Neurodegeneration

Tau Proteostasis and Clearance Across 4R-Tauopathies