protein 852 words KG: SUMO1PROTEIN
Contents

SUMO1 Protein - Small Ubiquitin-Like Modifier 1

🔬 Protein Info
Gene SymbolSUMO1
Full NameSmall Ubiquitin-Like Modifier 1
AliasesPage for SUMO1 Protein
Chromosome2q33
FunctionSUMO1 encodes a small ubiquitin-like protein (~101 amino acids) that can be covalently attached to lysine residues in target proteins through an enzymatic cascade involving E1, E2, and E3 enzymes.
Primary ExpressionUbiquitous - High in brain, heart, liver
Molecular Weight11.6 kDa
Amino Acids101 aa
UniProt IDP63165
NCBI Gene ID7341
Ensembl IDENSG00000116030
OMIM601561
GeneCardsSUMO1
Human Protein AtlasSUMO1
Associated DiseasesAls
InteractionsATG12, ATG5, ATG7, HIF1A, LC3, MFN1
KG Connections39 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (6)

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (9)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.