protein

ATG7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1349Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

ATG7 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA. Connected to 662 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATG7
Full Name	Autophagy Related 7
Chromosome	3p22.1
Protein Type	Protein
Function	is an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight	78 kDa
Gene Type	Protein-coding
Pathways	Angiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt ID	O95352
NCBI Gene ID	9459
Ensembl ID	ENSG00000198271
OMIM	607760
GeneCards	ATG7
Human Protein Atlas	ATG7
Disease	Inheritance
Associated Diseases	ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	RAPAMYCIN, CURCUMIN, curcumin, nicotinamide, rapamycin
Interactions	JUN, SQSTM1, MAP2, SYN1, MAP1LC3B, SNAP25
KG Connections	1342 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATG7 — AlphaFold O95352 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ATG7(["ATG7"])
    Autophagy("Autophagy")
    Als["Als"]
    Apoptosis["Apoptosis"]
    LC3(["LC3"])
    AUTOPHAGY(["AUTOPHAGY"])
    APOPTOSIS(["APOPTOSIS"])
    P62(["P62"])
    Cancer["Cancer"]
    Tumor["Tumor"]
    autophagy["autophagy"]
    FTO(["FTO"])

    ATG7 -->|"associated with"| Autophagy
    ATG7 -->|"activates"| Als
    ATG7 -->|"activates"| Autophagy
    ATG7 -->|"activates"| Apoptosis
    ATG7 -->|"activates"| LC3
    ATG7 -->|"activates"| AUTOPHAGY
    APOPTOSIS -->|"activates"| ATG7
    AUTOPHAGY -->|"activates"| ATG7
    ATG7 -->|"activates"| P62
    ATG7 -->|"activates"| Cancer
    ATG7 -->|"activates"| Tumor
    ATG7 -->|"activates"| autophagy
    ATG7 -->|"participates in"| autophagy
    ATG7 -->|"involved in"| Autophagy
    FTO -->|"regulates"| ATG7

    style ATG7 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (909)

Target	Relation	Type	Str
LC3	activates	gene	1.00
Autophagy	associated_with	pathway	1.00
Als	activates	disease	1.00
Autophagy	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
P62	activates	gene	1.00
Cancer	activates	disease	0.95
Tumor	activates	disease	0.95
autophagy	activates	pathway	0.90
autophagy	participates_in	pathway	0.90
Autophagy	involved_in	process	0.90
MTOR	activates	gene	0.90
Mtor	activates	pathway	0.90
Autophagy	regulates	pathway	0.90
AMPK	activates	gene	0.90
CANCER	activates	gene	0.90
Inflammation	activates	disease	0.85
Ferroptosis	contributes_to	process	0.85
oxidative stress response	participates_in	pathway	0.80
Oxidative Stress	activates	pathway	0.80
AUTOPHAGY	associated_with	gene	0.80
Inflammation	inhibits	disease	0.75
Als	inhibits	disease	0.75
Aging	regulates	disease	0.75
Tumor	associated_with	disease	0.75
Alzheimer	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Lung Cancer	activates	disease	0.75
SQSTM1	activates	gene	0.70
MAP1LC3B	activates	gene	0.70
MAP1LC3B	associated_with	gene	0.70
LC3	associated_with	gene	0.70
LC3	inhibits	gene	0.70
ULK1	inhibits	gene	0.70
macroautophagy	regulates	process	0.70
P62	inhibits	gene	0.70
MTOR	expressed_in	gene	0.70
PARKIN	regulates	gene	0.70
SIRT1	activates	gene	0.70
ferroptosis	participates_in	pathway	0.70
Mtor	associated_with	pathway	0.70
Apoptosis	associated_with	pathway	0.70
Ferroptosis	activates	pathway	0.70
mitophagy	regulates	process	0.70
DNA	associated_with	gene	0.70
GENES	activates	gene	0.70
Oxidative Stress	inhibits	pathway	0.70
Autophagy	inhibits	pathway	0.70
Mitophagy	activates	pathway	0.70

Incoming (440)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
paeoniflorin	contributes_to	drug	0.90
FTO	regulates	protein	0.90
YTHDF2	inhibits	protein	0.90
ATG5	associated_with	gene	0.90
ATG5	activates	gene	0.90
CLOCK	regulates	gene	0.80
rapamycin	targets	drug	0.80
LC3	activates	gene	0.80
BECN1	associated_with	gene	0.80
TNF	inhibits	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
ROS	activates	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
LC3	associated_with	gene	0.70
CASP1	associated_with	gene	0.70
BNIP3	activates	gene	0.70
BECN1	activates	gene	0.70
SQSTM1	activates	gene	0.70
ATG16L1	associated_with	gene	0.70
FIP200	associated_with	gene	0.70
P62	inhibits	gene	0.70
ATG3	inhibits	gene	0.70
BECLIN1	activates	gene	0.70
MAP1LC3A	associated_with	gene	0.70
ATG5	expressed_in	gene	0.70
ACTB	regulates	gene	0.70
ATG	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
APOPTOSIS	associated_with	gene	0.70
ERK	inhibits	gene	0.70
AUTOPHAGY	regulates	gene	0.70
AKT	associated_with	gene	0.65
AKT	activates	gene	0.65
ATG5	increases	gene	0.65
ATG5	reduces	gene	0.65
AKT	phosphorylates	gene	0.65
CARFILZOMIB	protects_against	drug	0.65
ASTROCYTE	associated_with	gene	0.65
JMJD3	regulates	protein	0.64
ACTB	associated_with	gene	0.60
LAMP1	activates	gene	0.60
MTOR	activates	gene	0.60
TUBB3	activates	gene	0.60
GABARAP	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG7

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG7 Gene

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

rapamycin-tauopathy

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Pathway Diagram

Outgoing (909)

Incoming (440)

Targeting Hypotheses (0)

Mentioning Analyses (4)

Epigenetic reprogramming in aging neurons

Epigenetic clocks and biological aging in neurodegeneration

Sleep disruption as cause and consequence of neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Related Papers (0)

ATG7

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG7 Gene

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

rapamycin-tauopathy

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

Circadian Disruption in Neurodegeneration

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

autophagy-lysosome-dysfunction

Sirtuin Signaling in Parkinson's Disease

MAP1LC3A Gene

Lysosomal Dysfunction in Progressive Supranuclear Palsy

Tau Proteostasis and Clearance Across 4R-Tauopathies

SIVA1 — SIVA Apoptosis-Inducing Factor

Glutamate Excitotoxicity Pathway in Neurodegeneration

Autophagy-Lysosomal Pathway

Mitophagy

Autophagy Types in Neurodegeneration

Autophagy-Impaired Neurons

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

Pathway Diagram

Outgoing (909)

Incoming (440)

Targeting Hypotheses (0)

Mentioning Analyses (4)

Epigenetic reprogramming in aging neurons

Epigenetic clocks and biological aging in neurodegeneration

Sleep disruption as cause and consequence of neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Related Papers (0)