protein

ATG7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1428Connections

3Hypotheses

9Analyses

50Outgoing

50Incoming

0Experiments

19Debates

Summary

ATG7 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA. Connected to 662 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	ATG7
Full Name	Autophagy Related 7
Chromosome	3p22.1
Protein Type	Protein
Function	is an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight	78 kDa
Pathways	Angiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt ID	O95352
NCBI Gene ID	9459
Ensembl ID	ENSG00000198271
OMIM	607760
GeneCards	ATG7
Human Protein Atlas	ATG7
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	curcumin, CURCUMIN, nicotinamide, rapamycin, RAPAMYCIN
Interactions	ACETYL-COA, ACHE, ACSL4, ACTB, Actin, AD
SciDEX Hypotheses	Astrocyte-specific autophagy deficiency induces NA Autophagy Enhancement for Tau Clearance Oligodendroglial Autophagy Enhancement
KG Connections	1420 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATG7 — AlphaFold O95352 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ATG7(["ATG7"])
    Autophagy("Autophagy")
    Als["Als"]
    Apoptosis["Apoptosis"]
    LC3(["LC3"])
    AUTOPHAGY(["AUTOPHAGY"])
    APOPTOSIS(["APOPTOSIS"])
    P62(["P62"])
    Cancer["Cancer"]
    Tumor["Tumor"]
    autophagy["autophagy"]
    FTO(["FTO"])

    ATG7 -->|"associated with"| Autophagy
    ATG7 -->|"activates"| Als
    ATG7 -->|"activates"| Autophagy
    ATG7 -->|"activates"| Apoptosis
    ATG7 -->|"activates"| LC3
    ATG7 -->|"activates"| AUTOPHAGY
    APOPTOSIS -->|"activates"| ATG7
    AUTOPHAGY -->|"activates"| ATG7
    ATG7 -->|"activates"| P62
    ATG7 -->|"activates"| Cancer
    ATG7 -->|"activates"| Tumor
    ATG7 -->|"activates"| autophagy
    ATG7 -->|"participates in"| autophagy
    ATG7 -->|"involved in"| Autophagy
    FTO -->|"regulates"| ATG7

    style ATG7 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (985)

Target	Relation	Type	Str
ATG7	encodes	protein	0.00
benchmark_ot_ad_answer_key:ATG7	data_in	dataset_row	0.00
Als	activates	disease	1.00
Autophagy	activates	pathway	1.00
autophagy	activates	pathway	1.00
LC3	activates	gene	1.00
Autophagy	associated_with	pathway	1.00
Apoptosis	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
P62	activates	gene	1.00
Cancer	activates	disease	0.95
Tumor	activates	disease	0.95
autophagy	regulates	phenotype	0.90
autophagy_pathway	regulates	pathway	0.90
autophagy	participates_in	pathway	0.90
Autophagy	regulates	pathway	0.90
AMPK	activates	gene	0.90
MTOR	activates	gene	0.90
Mtor	activates	pathway	0.90
CANCER	activates	gene	0.90
Inflammation	activates	disease	0.85
Ferroptosis	associated_with	process	0.85
mitochondrial fragmentation	regulates	phenotype	0.80
oxidative stress response	participates_in	pathway	0.80
Non-Alcoholic Fatty Liver Disease	biomarker_for	disease	0.80
Oxidative Stress	activates	pathway	0.80
AUTOPHAGY	associated_with	gene	0.80
Aging	regulates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Inflammation	inhibits	disease	0.75
Als	inhibits	disease	0.75
Tumor	associated_with	disease	0.75
Lung Cancer	activates	disease	0.75
Alzheimer	activates	disease	0.75
NRF2	activates	gene	0.70
VCP	regulates	gene	0.70
VEGF	activates	gene	0.70
IGF1	activates	gene	0.70
TFEB	markers	gene	0.70
SQSTM1	markers	gene	0.70
SQSTM1	degrades	gene	0.70
NRF2	expresses	gene	0.70
VAMP2	regulates	gene	0.70
ENDOTHELIAL	interacts_with	cell_type	0.70
CCL2	interacts_with	gene	0.70
CNP	regulates	gene	0.70
SYN1	regulates	gene	0.70
GRIN2B	regulates	gene	0.70
SYT1	regulates	gene	0.70
MBP	activates	gene	0.70

Incoming (443)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG7	data_in	dataset_row	0.00
ATG7	encodes	gene	0.00
APOPTOSIS	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
ginseng root extract	contributes_to	drug	0.90
YTHDF2	inhibits	protein	0.90
FTO	regulates	protein	0.90
paeoniflorin	contributes_to	drug	0.90
TFEB	induces_transcription	transcription_factor	0.90
ATG5	activates	gene	0.90
ATG5	associated_with	gene	0.90
rapamycin	targets	drug	0.80
CLOCK	regulates	gene	0.80
BECN1	associated_with	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
ROS	activates	gene	0.80
TNF	inhibits	gene	0.80
LC3	activates	gene	0.80
ATG5	targets	gene	0.70
ATG5	mediates	gene	0.70
ACHE	activates	gene	0.70
ATG5	biomarker_for	gene	0.70
ATG16L1	associated_with	gene	0.70
ATG	activates	gene	0.70
ATG3	inhibits	gene	0.70
BNIP3	activates	gene	0.70
BECN1	activates	gene	0.70
FIP200	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
MITOPHAGY	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
MAP1LC3A	associated_with	gene	0.70
P62	inhibits	gene	0.70
ACTB	regulates	gene	0.70
LC3	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
ERK	inhibits	gene	0.70
CASP1	associated_with	gene	0.70
ATG5	expressed_in	gene	0.70
SQSTM1	activates	gene	0.70
BECLIN1	activates	gene	0.70
ASTROCYTE	associated_with	gene	0.65
AKT	associated_with	gene	0.65
AKT	phosphorylates	gene	0.65
AKT	activates	gene	0.65
CARFILZOMIB	protects_against	drug	0.65
JMJD3	regulates	protein	0.64
SQSTM1	inhibits	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-specific autophagy deficiency induces NADPH oxidas	0.390	als	How do non-cell autonomous effects of au
Autophagy Enhancement for Tau Clearance	0.000	-	4R-tau strain-specific spreading pattern
Oligodendroglial Autophagy Enhancement	0.000	-	How do non-cell autonomous effects of au

Mentioning Analyses (9)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (19)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning ATG7 in their description or question text

No additional research found

ATG7

Understanding Entity Pages

Summary

Wiki Pages (3)

ATG7 Protein — Autophagy-Related Protein 7

ATG7 Protein

ATG7 Gene

Pathway Diagram

Outgoing (985)

Incoming (443)

Targeting Hypotheses (3)

Mentioning Analyses (9)

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

Epigenetic reprogramming in aging neurons

Senescent cell clearance as neurodegeneration therapy

Epigenetic clocks and biological aging in neurodegeneration

Sleep disruption as cause and consequence of neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

4R-tau strain-specific spreading patterns in PSP vs CBD

Experiments (0)

Related Papers (0)

Debates (19)

Extended debate: Metabolic Reprogramming to Reverse Senescence

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

The debate identified this as a critical mechanistic gap - TFEB may increase lys

Related Research