gene

MFN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MFN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

922Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MFN1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 397 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MFN1
Chromosome	3q26.33
Function	Mitofusin 1 (MFN1) is a dynamin-like GTPase essential for mitochondrial outer membrane fusion
Primary Expression	hippocampus, Cerebellum, Cortex, Striatum, Substantia Nigra
Molecular Weight	83 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Lysosomal Degradation, Mitochondrial Function
GeneCards	MFN1
Human Protein Atlas	MFN1
Associated Diseases	AD, ALI, Als, Alzheimer, COPD
Interactions	ABCD3, Actin, AGING, AKT, ALS, ALZHEIMER
KG Connections	921 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MFN1["MFN1"] -->|"Interacts With"| Dementia["Dementia"]
    MFN1["MFN1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    MFN1["MFN1"] -->|"Interacts With"| Als["Als"]
    MFN1["MFN1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    MFN1["MFN1"] -->|"Interacts With"| Parkinson["Parkinson"]
    MFN1["MFN1"] -->|"Interacts With"| Ms["Ms"]
    MFN1["MFN1"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MFN1["MFN1"] -->|"Interacts With"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CAT["CAT"] -->|"Interacts With"| MFN1["MFN1"]
    OPTN["OPTN"] -->|"Interacts With"| MFN1["MFN1"]
    DNM1L["DNM1L"] -->|"Interacts With"| MFN1["MFN1"]
    CANX["CANX"] -->|"Interacts With"| MFN1["MFN1"]
    LGALS3["LGALS3"] -->|"Interacts With"| MFN1["MFN1"]
    style MFN1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Frontotemporal_Dementia fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (527)

Target	Relation	Type	Str
MFN1	encodes	protein	0.00
mitochondrial fusion	promotes	process	0.95
Mitochondrial fusion	activates	process	0.90
Mitochondrial Fusion	mediates	process	0.88
mitochondrial fusion	involved_in	process	0.85
autophagy	regulates	process	0.85
Mitochondrial Fusion	promotes	process	0.85
nutrient deprivation	modulates	process	0.80
Inflammation	activates	disease	0.75
Als	expressed_in	disease	0.75
Als	activates	disease	0.75
mitochondrial dynamics	participates_in	pathway	0.70
Oxidative Stress	activates	pathway	0.70
MITOPHAGY	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
Mitophagy	activates	pathway	0.70
OPA1	inhibits	gene	0.70
TFAM	activates	gene	0.70
Fibrosis	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Obesity	regulates	disease	0.65
Parkinson	activates	disease	0.65
ALS	interacts_with	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Diabetes	biomarker_for	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Cardiovascular	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Aging	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Diabetes	expressed_in	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ischemia	inhibits	disease	0.65

Incoming (395)

Source	Relation	Type	Str
MFN1	encodes	gene	0.00
PM10	downregulates	compound	0.85
Paclitaxel	downregulates	drug	0.85
NEURONS	inhibits	cell_type	0.70
MFN2	inhibits	gene	0.70
Copper	inhibits	drug	0.70
PARKIN	modifies	gene	0.70
DEMENTIA	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
RUNX2	activates	gene	0.60
MFN2	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
MITOCHONDRIA	activates	gene	0.60
BECLIN1	expressed_in	gene	0.60
ALS	interacts_with	gene	0.60
ABCD3	activates	entity	0.60
BCL2L11	activates	entity	0.60
BCL2L13	activates	entity	0.60
BECN1	activates	entity	0.60
BNIP3	activates	entity	0.60
DRP1	upregulates	entity	0.60
PPARGC1A	regulates	gene	0.60
LARS2	inhibits	gene	0.60
ZAP70	biomarker_for	gene	0.60
AMBRA1	activates	entity	0.60
EMD	activates	entity	0.60
OPA1	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
GUT-BRAIN AXIS	activates	gene	0.60
HIF1	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
MFN2	regulates	gene	0.60
REEP5	interacts_with	gene	0.60
PLIN1	activates	gene	0.60
CD4	biomarker_for	gene	0.60
DNM1L	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
NRF1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MFN1 in their description or question text

No additional research found