gene

MFN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MFN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

931Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

MFN1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 397 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MFN1
Chromosome	3q26.33
Function	Mitofusin 1 (MFN1) is a dynamin-like GTPase essential for mitochondrial outer membrane fusion
Primary Expression	hippocampus, Cerebellum, Cortex, Striatum, Substantia Nigra
Molecular Weight	83 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Lysosomal Degradation, Mitochondrial Function
GeneCards	MFN1
Human Protein Atlas	MFN1
Associated Diseases	AD, ALI, ALS, Alzheimer, COPD
Interactions	ERN1, PARKIN, FMR1, SNCA, FAM134B, LC3
KG Connections	931 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MFN1["MFN1"] -->|"Interacts With"| Dementia["Dementia"]
    MFN1["MFN1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    MFN1["MFN1"] -->|"Interacts With"| Als["Als"]
    MFN1["MFN1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    MFN1["MFN1"] -->|"Interacts With"| Parkinson["Parkinson"]
    MFN1["MFN1"] -->|"Interacts With"| Ms["Ms"]
    MFN1["MFN1"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MFN1["MFN1"] -->|"Interacts With"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CAT["CAT"] -->|"Interacts With"| MFN1["MFN1"]
    OPTN["OPTN"] -->|"Interacts With"| MFN1["MFN1"]
    DNM1L["DNM1L"] -->|"Interacts With"| MFN1["MFN1"]
    CANX["CANX"] -->|"Interacts With"| MFN1["MFN1"]
    LGALS3["LGALS3"] -->|"Interacts With"| MFN1["MFN1"]
    style MFN1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Frontotemporal_Dementia fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (532)

Target	Relation	Type	Str
mitochondrial fusion	promotes	process	0.95
Mitochondrial fusion	activates	process	0.90
Mitochondrial Fusion	mediates	process	0.88
autophagy	regulates	process	0.85
Mitochondrial Fusion	promotes	process	0.85
mitochondrial fusion	involved_in	process	0.85
nutrient deprivation	modulates	process	0.80
Als	activates	disease	0.75
Inflammation	activates	disease	0.75
Als	expressed_in	disease	0.75
TFAM	activates	gene	0.70
OPA1	inhibits	gene	0.70
mitochondrial dynamics	participates_in	pathway	0.70
MITOPHAGY	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Huntington	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Stroke	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Ischemia	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Hypertension	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Als	regulates	disease	0.65
Als	inhibits	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65

Incoming (399)

Source	Relation	Type	Str
Paclitaxel	downregulates	drug	0.85
PM10	downregulates	compound	0.85
MFN2	inhibits	gene	0.70
PARKIN	modifies	gene	0.70
Copper	inhibits	drug	0.70
NEURONS	inhibits	cell_type	0.70
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
NRF1	activates	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
SIRT1	therapeutic_target	gene	0.60
DNM1L	therapeutic_target	gene	0.60
DRP1	activates	gene	0.60
PRKAA1	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
OPA1	activates	gene	0.60
DNM1L	regulates	gene	0.60
RAB5C	interacts_with	gene	0.60
MFN2	interacts_with	gene	0.60
DRP1	biomarker_for	gene	0.60
DRP1	regulates	gene	0.60
DRP1	inhibits	gene	0.60
DRP1	expressed_in	gene	0.60
BNIP3	interacts_with	gene	0.60
MFN2	associated_with	gene	0.60
MFN2	regulates	gene	0.60
REEP5	interacts_with	gene	0.60
PLIN1	activates	gene	0.60
CD4	biomarker_for	gene	0.60
ZAP70	biomarker_for	gene	0.60
BCL2L11	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MFN1

Understanding Entity Pages

Summary

Wiki Pages (21)

Mitofusin 1 (MFN1)

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

Insulin Signaling in Parkinson's Disease

Motor Neuron Disease (MND)

mitochondrial-dynamics-dysfunction-parkinsons

DDX3X Gene

Mitochondria

Chaperone-Mediated Autophagy in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

Mitochondrial Dysfunction in Progressive Supranuclear Palsy

RICTOR Protein

Mitochondria in Neurodegeneration

CNTFR Gene

Protein O-GlcNAcylation Pathway in Neurodegeneration

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease