gene

MFN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MFN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

922Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MFN1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 397 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	MFN1
Chromosome	3q26.33
Function	Mitofusin 1 (MFN1) is a dynamin-like GTPase essential for mitochondrial outer membrane fusion
Primary Expression	hippocampus, Cerebellum, Cortex, Striatum, Substantia Nigra
Molecular Weight	83 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Lysosomal Degradation, Mitochondrial Function
GeneCards	MFN1
Human Protein Atlas	MFN1
Associated Diseases	AD, ALI, Als, Alzheimer, COPD
Interactions	ABCD3, Actin, AGING, AKT, ALS, ALZHEIMER
KG Connections	921 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MFN1["MFN1"] -->|"Interacts With"| Dementia["Dementia"]
    MFN1["MFN1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    MFN1["MFN1"] -->|"Interacts With"| Als["Als"]
    MFN1["MFN1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    MFN1["MFN1"] -->|"Interacts With"| Parkinson["Parkinson"]
    MFN1["MFN1"] -->|"Interacts With"| Ms["Ms"]
    MFN1["MFN1"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MFN1["MFN1"] -->|"Interacts With"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CAT["CAT"] -->|"Interacts With"| MFN1["MFN1"]
    OPTN["OPTN"] -->|"Interacts With"| MFN1["MFN1"]
    DNM1L["DNM1L"] -->|"Interacts With"| MFN1["MFN1"]
    CANX["CANX"] -->|"Interacts With"| MFN1["MFN1"]
    LGALS3["LGALS3"] -->|"Interacts With"| MFN1["MFN1"]
    style MFN1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Frontotemporal_Dementia fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (527)

Target	Relation	Type	Str
MFN1	encodes	protein	0.00
mitochondrial fusion	promotes	process	0.95
Mitochondrial fusion	activates	process	0.90
Mitochondrial Fusion	mediates	process	0.88
Mitochondrial Fusion	promotes	process	0.85
autophagy	regulates	process	0.85
mitochondrial fusion	involved_in	process	0.85
nutrient deprivation	modulates	process	0.80
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
Als	expressed_in	disease	0.75
OXIDATIVE STRESS	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
MITOPHAGY	activates	gene	0.70
TFAM	activates	gene	0.70
OPA1	inhibits	gene	0.70
mitochondrial dynamics	participates_in	pathway	0.70
Inflammation	regulates	disease	0.65
Parkinson	activates	disease	0.65
Ftd	interacts_with	disease	0.65
ALS	inhibits	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Diabetes	regulates	disease	0.65
Obesity	regulates	disease	0.65
Huntington	associated_with	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Diabetes	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Stroke	regulates	disease	0.65
Ms	associated_with	disease	0.65
Dementia	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
ALS	activates	disease	0.65
Cardiac	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Ms	biomarker_for	disease	0.65
Cardiac	regulates	disease	0.65

Incoming (395)

Source	Relation	Type	Str
MFN1	encodes	gene	0.00
PM10	downregulates	compound	0.85
Paclitaxel	downregulates	drug	0.85
MFN2	inhibits	gene	0.70
PARKIN	modifies	gene	0.70
NEURONS	inhibits	cell_type	0.70
Copper	inhibits	drug	0.70
REEP5	interacts_with	gene	0.60
PLIN1	activates	gene	0.60
CD4	biomarker_for	gene	0.60
ZAP70	biomarker_for	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
MFN2	associated_with	gene	0.60
LC3	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
EIF2S1	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MAPK8	activates	entity	0.60
APP	inhibits	gene	0.60
PPARGC1A	regulates	gene	0.60
MFN2	activates	gene	0.60
TAU	inhibits	gene	0.60
SNCA	interacts_with	gene	0.60
MFN2	regulates	gene	0.60
FIS1	activates	gene	0.60
AMPK	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
NAD	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
C-MYC	regulates	gene	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
MAP1LC3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MFN1 in their description or question text

No additional research found