protein 974 words KG: TRKC 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

TrkC Protein

🔬 Protein Info
Gene SymbolTRKC
Chromosome15q25.3
Protein TypeReceptor
FunctionTrkC is the primary receptor for neurotrophin-3 (NT-3)
Primary Expressionproprioceptive neurons, motor neurons, and certain populations of hippocampal and cortical neurons
Subcellular Localization</strong></td><td>Plasma membrane, endosomes</td></tr>
Molecular Weight145 kDa
Amino Acids821 aa
Exons26
Pathwayssignaling: - Supports sensory neuron survival, PI3K, MAPK
GeneCardsTRKC
Human Protein AtlasTRKC
Associated DiseasesAlzheimer
InteractionsTRKB, TRKA, BDNF, NGF, ALZHEIMER, AMYLOID
KG Connections73 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (12)

Dynein Motor Protein
mechanism · KG edge: transports
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
MAP1B Gene
gene · KG edge: transports
BDNF Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

TRKC regulates TRKB
TRKC interacts_with TRKB
TRKC interacts_with TRKA
TRKC transports Schwann Cell
TRKC transports Dynein
TRKC regulates APP
TRKC associated_with NTRK2
TRKC interacts_with BDNF
TRKC interacts_with NGF
TRKC activates Alzheimer