disease

late

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about late: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

528Connections

7Hypotheses

30Analyses

50Outgoing

25Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	TREM2, LRRK2, APOE4, GLAUCOMA
KG Connections	374 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    late["<b>late</b>"]
    NEURONS["NEURONS"]
    late -->|"associated with"| NEURONS
    NEURONS["NEURONS"]
    late -->|"activates"| NEURONS
    INTERNEURONS["INTERNEURONS"]
    late -->|"activates"| INTERNEURONS
    PARP1["PARP1"]
    late -->|"activates"| PARP1
    IL1B["IL1B"]
    late -->|"activates"| IL1B
    DAPK1["DAPK1"]
    late -->|"activates"| DAPK1
    TUMOR["TUMOR"]
    late -->|"activates"| TUMOR
    apoptosis["apoptosis"]
    late -->|"activates"| apoptosis
    ALZHEIMER["ALZHEIMER"]
    late -->|"interacts with"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    late -->|"interacts with"| Alzheimer_S_Disease
    Genes["Genes"]
    late -->|"interacts with"| Genes
    disease["disease"]
    late -->|"interacts with"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    late -->|"interacts with"| ALZHEIMER_S
    cancer["cancer"]
    late -->|"regulates"| cancer
    METASTASIS["METASTASIS"]
    late -->|"regulates"| METASTASIS
    NETRIN_1["NETRIN-1"]
    late -->|"activates"| NETRIN_1
    CARCINOMA["CARCINOMA"]
    late -->|"activates"| CARCINOMA
    cancer["cancer"]
    late -->|"protects against"| cancer
    UNC5B["UNC5B"]
    late -->|"activates"| UNC5B
    LDLR["LDLR"]
    late -->|"associated with"| LDLR
    LDL_RECEPTOR["LDL RECEPTOR"]
    late -->|"associated with"| LDL_RECEPTOR
    ALZHEIMER["ALZHEIMER"]
    late -->|"associated with"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    late -->|"associated with"| Alzheimer_S_Disease
    disease["disease"]
    late -->|"associated with"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    late -->|"associated with"| ALZHEIMER_S
    LRP1["LRP1"]
    late -->|"inhibits"| LRP1
    AMYLOID["AMYLOID"]
    late -->|"inhibits"| AMYLOID
    AMYLOID__["AMYLOID-beta"]
    late -->|"inhibits"| AMYLOID__
    APOE["APOE"]
    late -->|"associated with"| APOE
    APOE["APOE"]
    late -->|"activates"| APOE

Outgoing (481)

Target	Relation	Type	Str
PARP1	activates	gene	0.50
IL1B	activates	gene	0.50
DAPK1	activates	gene	0.50
cancer	regulates	disease	0.50
cancer	protects_against	disease	0.50
UNC5B	activates	gene	0.50
LDLR	associated_with	gene	0.50
LRP1	inhibits	gene	0.50
APOE	associated_with	gene	0.50
APOE	activates	gene	0.50
APOE	regulates	gene	0.50
RILP	causes	gene	0.50
RAB7	causes	gene	0.50
RILP	activates	gene	0.50
RAB7	activates	gene	0.50
RAB7A	regulates	protein	0.50
RGS6	inhibits	gene	0.50
RANK	activates	gene	0.50
RAD51	inhibits	gene	0.50
EIF2AK3	inhibits	gene	0.50
ERN1	inhibits	gene	0.50
LDLR	activates	gene	0.50
UNC5C	associated_with	gene	0.50
BIN1	activates	gene	0.50
BIN1	associated_with	gene	0.50
BIN1	regulates	gene	0.50
nmosd	activates	disease	0.50
APOE	expressed_in	gene	0.50
cancer	activates	disease	0.50
VPS4A	inhibits	gene	0.50
GFAP	associated_with	gene	0.50
GFAP	activates	gene	0.50
APOE	interacts_with	gene	0.50
cancer	associated_with	disease	0.50
OPTN	associated_with	gene	0.50
OPTINEURIN	associated_with	protein	0.50
OPTN	inhibits	gene	0.50
NPC1	associated_with	protein	0.50
RORB	expressed_in	gene	0.50
FGF14	activates	gene	0.50
RORA	activates	gene	0.50
GRIN2A	activates	gene	0.50
NCAM2	activates	gene	0.50
NRXN1	activates	protein	0.50
KCNIP4	activates	gene	0.50
REELIN	activates	protein	0.50
MLCK	activates	gene	0.50
CYP46A1	expressed_in	gene	0.50
SYNCRIP	associated_with	concept	0.50
SYNCRIP	interacts_with	concept	0.50

Incoming (47)

Source	Relation	Type	Str
TREM2	activates	gene	0.50
TREM2	inhibits	gene	0.50
TREM2	associated_with	gene	0.50
TYROBP	activates	gene	0.50
TREM2	expressed_in	gene	0.50
apoe2	interacts_with	disease	0.50
APOE4	interacts_with	gene	0.50
LRRK2	causes	gene	0.50
LRRK2	associated_with	gene	0.50
CD33	activates	gene	0.50
CD33	interacts_with	gene	0.50
CD33	expressed_in	gene	0.50
APOE4	associated_with	gene	0.50
LRRK2	interacts_with	gene	0.50
LRRK2	regulates	gene	0.50
LRRK2	activates	gene	0.50
Neuroinflammation	associated_with	process	0.50
PHAGOCYTOSIS	activates	gene	0.50
DEPRESSION	interacts_with	disease	0.50
DEPRESSION	associated_with	disease	0.50
Neuroinflammation	activates	process	0.50
APOE3	interacts_with	protein	0.50
GLAUCOMA	associated_with	gene	0.50
Neuroinflammation	interacts_with	process	0.50
DEPRESSION	activates	disease	0.50

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.569	neurodegeneration	Lipid raft composition changes in synapt
Near-infrared light therapy stimulates COX4-dependent mitoch	0.514	neurodegeneration	Mitochondrial transfer between astrocyte
Layer V excitatory neurons show selectively enhanced vulnera	0.510	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Glycosaminoglycan Template Disruption Approach	0.464	neurodegeneration	Protein aggregation cross-seeding across
TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinf	0.444	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (30)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.542

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

neurodegeneration | 2026-04-15 | 0 hypotheses

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096]	Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li	Autophagy	2023	1
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains. [PMID:32722981]	Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W	Autophagy	2021	1
SIRT5 regulation of ammonia-induced autophagy and mitophagy. [PMID:25700560]	Polletta L, Vernucci E, Carnevale I, Arc	Autophagy	2015	1
Enhancing the efficiency of bone tissue regeneration by using a 3D printed scaff [PMID:41435437]	Ku CY, Chen YH, Lin CM, Chu YH, Ho YJ, L	Biomedical materials (Bristol,	2026	0
PRKAB2 as a tumor suppressor in renal cell carcinoma: inhibiting mitophagy via t [PMID:41612594]	Chen K, Zhang Y, Ruan H, Wei Z, Wang K,	Autophagy	2026	0
ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818]	["Li X", "Huang J", "Zhou Y", "Chen X",	International journal of pharm	2026	0
Single-Cell RNA Sequencing and Network Pharmacology Reveal the Potential Role of [PMID:41610872]	["Niu J", "Wang L", "Qi J", "Lu G"]	The journal of gene medicine	2026	0
Integrated Profiling of DEHP-Induced Hippocampal Neurotoxicity in Adult Female R [PMID:41600627]	Bai J, Li J, Tang L, Sun W, Gao F, Zhang	Toxics	2026	0
Functional and Molecular Characterization of Melamine-Induced Disruption of Huma [PMID:41596180]	["Luongo F", "Annunzi E", "Ponchia R", "	Antioxidants (Basel, Switzerla	2026	0
Exploring the lactate-metabolism related characteristics during the development [PMID:41815173]	Wang C, Zhang R, Li S, Kang Z, Xia S, Li	Translational cancer research	2026	0
Developmental toxicity of carboxylated microplastics in zebrafish mediated by mi [PMID:41265820]	["Li Y", "Ni Y", "Dong C", "Zhang J", "G	Environmental pollution (Barki	2026	0
Complex IV deficiency due to COX4I1 deep intronic and de novo variants results i [PMID:41203052]	Ugarteburu O, Farré-Tarrats L, Muñoz-Puj	Mitochondrion	2026	0
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026	0
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026	0
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026	0
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026	0
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929]	Mateus-Tique J, Lakshmi A, Singh B, Iyer	Cancer Cell	2026	0
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026	0
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026	0
Large-scale single-cell analysis and in silico perturbation reveal dynamic evolu [PMID:41617928]	Xia P, Shuang S, Fu D, Liu L, Yang D et	NPJ Precis Oncol	2026	0

late

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nimodipine-als

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Alzheimer's Disease

PD Cure Roadmap

Pathway Diagram

Outgoing (481)

Incoming (47)

Targeting Hypotheses (7)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

How do the seven novel ALS genes function in animal models to cause neurodegener

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

What are the specific molecular mechanisms by which peripheral monocytes cross t

Does human glymphatic function show clinically relevant circadian variation like

What specific gene expression signatures in aging mouse white matter predict hum

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

Does structural 'normalization' of APOE4 domain interactions actually improve am

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

Do stellate neurons express unique α7 nicotinic receptor subtypes that could ena

Why do clinical manifestations overlap despite distinct underlying etiologies in

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Can circadian interventions reverse microglial priming independent of sleep disr

What are the specific pathophysiological mechanisms underlying uncommon immune-m

What determines the spatial organization of autophagy receptors at stress granul

What are the specific molecular mechanisms by which C1Q components drive atheros

Do perinatal immune challenges create persistent epigenetic modifications that p

What determines P2RY12 receptor expression/activity specifically in VSMCs during

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Related Papers (20)