| Gene Symbol | UBA1 |
| Aliases | E1 Ubiquitin-Activating Enzyme |
| Function | Adenylation: UBA1 binds ATP and ubiquitin, forming a ubiquitin-adenylate intermediate |
| Subcellular Localization | ** | Nucleus (UBA1a), Cytoplasm (UBA1b) | |
| Molecular Weight | 117 kDa |
| Amino Acids | 058 aa |
| Pathways | NF-κB |
| Ensembl ID | ENSG00000130985 |
| GeneCards | UBA1 |
| Human Protein Atlas | UBA1 |
| Inactive adenylation domain (IAD) | N-terminal; structural role, no catalytic activity |
| Active adenylation domain (AAD) | Contains the ATP-binding site; catalyzes ubiquitin adenylation |
| Ubiquitin fold domain (UFD) | C-terminal; recruits and interacts with E2 enzymes |
| UBE2D family | General-purpose E2s for proteasomal targeting |
| UBE2N/UBE2V | K63-linked chain assembly for signaling |
| Associated Diseases | Senescence |
| Interactions | AGING, INFLAMMATION, NLRP3, PARK2, PINK1, PRKN |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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