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mechanism 1,407 words KG: SASP
Contents

SASP (Senescence-Associated Secretory Phenotype) in Neurodegeneration

⚙ Mechanism Info
NameSASP
Key Genes/ProteinsCDKN2A, cxcl10, MTOR
Related DiseasesAlzheimer's Disease, Alzheimer'S Disease, Aβ-induced neurotoxicity, fibrosis, microglial senescence
Related PathwaysBDNF expression, MAPK
Linked Hypotheses40 hypotheses

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Related Hypotheses (32)

TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagatio
Score: 0.00TBK1 Loss Triggers eIF2α-Mediated Translational Repression T
Score: 0.00TBK1 Loss Locks Microglia in an Aged/Senescent Transcription
Score: 0.88Microglial Senescence Prevention via TREM2/SASP Axis
Score: 0.84SASP-Mediated Complement Cascade Amplification
Score: 0.82Targeting SASP-Complement Amplification Through HIF-1α Downs
Score: 0.79SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76Complement-SASP Amplification Cascade as Mechanistic Link
Score: 0.74SASP Secretome-based Molecular Distinction via CXCL1/CXCL2/M
Score: 0.72SASP-Secreted MMP-9 from Senescent Microglia Generates Patho
Score: 0.72TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S
Score: 0.66SASP Modulation Rather Than Cell Elimination
Score: 0.66SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs
Score: 0.65SASP-Driven Microglial Metabolic Reprogramming in Synaptic P
Score: 0.64NAMPT-SIRT1 Axis as Master Regulator of SASP-Dependent Compl
Score: 0.59NLRP3 Inflammasome Blockade as Upstream Intervention to Prev
Score: 0.57Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc
Score: 0.56H2: SASP Neutralization via JAK/STAT Inhibition Preserves As
Score: 0.55Combined NAMPT-Alectinib Targeting of SASP-Complement Cascad
Score: 0.55
pg 1/2Next →

Knowledge Graph (12 edges)

SASP activates fibrosis
SASP activates neuroinflammation
Senescent Microglia associated_with SASP
SASP expressed_in Senescent Microglia
Senescent Microglia expressed_in SASP
SASP mediates chronic inflammation
senescent cells develops SASP
SASP promotes chronic inflammation
SASP promotes tissue dysfunction
NFKB1 promotes SASP

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