concept

CHRONIC INFLAMMATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRONIC INFLAMMATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

190Connections

0Hypotheses

1Analyses

45Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CHRONIC INFLAMMATION
Key Genes/Proteins	ASXL1, TP53, SF3B1, TET2, U2AF1, DNMT3A
Related Diseases	aging, Sarcopenia
Related Pathways	inflammation

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CHRONIC_INFLAMMATION["CHRONIC INFLAMMATION"]
    CHRONIC_INFLAMMATION -->|"contributes to"| Age_Related_Diseases["Age-Related Diseases"]
    CHRONIC_INFLAMMATION -->|"mediates"| Chronic_Diseases["Chronic Diseases"]
    CHRONIC_INFLAMMATION -->|"involved_in"| Heart_Failure["Heart Failure"]
    CHRONIC_INFLAMMATION -->|"promotes"| senescence["senescence"]
    CHRONIC_INFLAMMATION -->|"contributes to"| Memory_Impairment["Memory Impairment"]
    CHRONIC_INFLAMMATION -->|"contributes to"| Brain_Volume_Loss["Brain Volume Loss"]
    CHRONIC_INFLAMMATION -->|"contributes to"| Muscle_Wasting["Muscle Wasting"]
    CHRONIC_INFLAMMATION -->|"promotes"| age_related_diseases["age-related diseases"]
    Telomere_Dysfunction["Telomere Dysfunction"] -->|"causes"| CHRONIC_INFLAMMATION
    Aging["Aging"] -->|"causes"| CHRONIC_INFLAMMATION
    Inflammasome_Pathway["Inflammasome Pathway"] -->|"activates"| CHRONIC_INFLAMMATION
    CYTOKINES_AND_CHEMOKINES["CYTOKINES AND CHEMOKINES"] -->|"mediates"| CHRONIC_INFLAMMATION
    IL_6["IL-6"] -->|"promotes"| CHRONIC_INFLAMMATION
    Cellular_Senescence["Cellular Senescence"] -->|"contributes to"| CHRONIC_INFLAMMATION
    NLRP3["NLRP3"] -->|"promotes"| CHRONIC_INFLAMMATION
    C5a_C5aR1_Axis["C5a/C5aR1 Axis"] -->|"mediates"| CHRONIC_INFLAMMATION

Outgoing (45)

Target	Relation	Type	Str
Age-Related Diseases	contributes_to	disease	0.95
Chronic Diseases	mediates	disease	0.95
Age-Related Diseases	causes	disease	0.95
Chronic Obstructive Pulmonary Disease	mediates	disease	0.95
COPD	associated_with	disease	0.95
Parkinson'S Disease	associated_with	disease	0.95
Dementia	associated_with	disease	0.95
Memory Impairment	contributes_to	phenotype	0.90
Brain Volume Loss	contributes_to	phenotype	0.90
Muscle Wasting	contributes_to	phenotype	0.90
Progressive Multiple Sclerosis	associated_with	disease	0.90
Treatment Resistance	causes	phenotype	0.90
Copd Onset	contributes_to	process	0.90
Copd Progression	contributes_to	process	0.90
age-related neurodegenerative disorders	risk_factor_for	disease	0.90
Heart Failure	involved_in	disease	0.90
senescence	promotes	process	0.90
Neurodegeneration	contributes_to	process	0.90
Endometriosis	involved_in	disease	0.90
Cognitive Decline	contributes_to	phenotype	0.90
age-related diseases	promotes	disease	0.88
Alzheimer's Disease	associated_with	disease	0.88
Alzheimer'S Disease	associated_with	disease	0.88
Depressive Symptoms	causes	phenotype	0.85
Cardiac Degeneration	involved_in	process	0.85
Airflow Limitation	causes	phenotype	0.85
neurodegeneration	promotes	disease	0.85
Cardiovascular Disease	risk_factor_for	disease	0.85
Metabolic Disorders	risk_factor_for	disease	0.85
Memory Impairment	causes	phenotype	0.85
Brain Volume Loss	causes	phenotype	0.85
Cardiac Fibrosis	contributes_to	disease	0.85
Neurodegeneration	causes	process	0.85
Neuroinflammation	associated_with	process	0.85
Neurodegeneration	risk_factor_for	disease	0.85
Alzheimer'S Disease	contributes_to	disease	0.85
Alzheimer's Disease	risk_factor_for	disease	0.82
Cardiac Aging	involved_in	process	0.80
Sarcopenia	contributes_to	disease	0.80
Amyloid Pathology	associated_with	mechanism	0.75
neuronal deregulation	activates	process	0.70
SARCOPENIA	causes	disease	0.70
cognitive decline	causes	disease	0.70
Alzheimer's disease	causes	disease	0.70
Depression	causes	disease	0.70

Incoming (145)

Source	Relation	Type	Str
CLONAL HEMATOPOIESIS	causes	entity	0.85
inflammation	interacts_with	pathway	0.50
ASXL1	activates	gene	0.50
TP53	activates	gene	0.50
SF3B1	activates	gene	0.50
TET2	activates	gene	0.50
U2AF1	activates	gene	0.50
DNMT3A	activates	protein	0.50
inflammation	activates	pathway	0.50
DNA DAMAGE	activates	concept	0.50
inflammation	associated_with	pathway	0.50
aging	associated_with	phenotype	0.50
Sarcopenia	associated_with	disease	0.50
ALZHEIMER	associated_with	gene	0.50
PARKINSON	associated_with	gene	0.50
DEMENTIA	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
Parkinson's Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
disease	interacts_with	disease	0.50
COPD	interacts_with	disease	0.50
Cardiovascular	associated_with	disease	0.50
Autophagy	regulates	process	0.50
inflammation	regulates	pathway	0.50
aging	regulates	phenotype	0.50
oxidative stress	regulates	phenotype	0.50
Cardiac	regulates	disease	0.50
Cellular Senescence	regulates	cell_type	0.50
FIBROSIS	associated_with	disease	0.50
Mitochondrial Function	associated_with	pathway	0.50
Neuroinflammation	activates	process	0.50
microglia	activates	cell_type	0.50
Neurodegeneration	activates	disease	0.50
disease	activates	disease	0.50
APOE4	regulates	gene	0.50
Neurodegeneration	regulates	disease	0.50
APOE	regulates	gene	0.50
microglia	regulates	cell_type	0.50
AMYLOID	regulates	gene	0.50
TAU PATHOLOGY	regulates	concept	0.50
AMYLOID-β	regulates	concept	0.50
NLRP3	activates	protein	0.50
CYTOKINES	activates	concept	0.50
Neuroinflammation	interacts_with	process	0.50
DEPRESSION	interacts_with	disease	0.50
AMYLOID	interacts_with	gene	0.50
OBESITY	interacts_with	disease	0.50
Gut Microbiome	interacts_with	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

neuroinflammation | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHRONIC INFLAMMATION

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Novel Therapy Index

Parkinson's Disease

Neuroresilience Mechanisms and Evidence

neuroinflammation

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

nlrc5-protein

Infectious Triggers in Alzheimer's Disease

Mitochondrial Dysfunction in Neurodegeneration

uni-pittsburgh

Benfotiamine Phase 2 Alzheimer's Disease Trial (NCT06223360)

GBA1→GCase→Lysosome→PD Causal Chain

Microglial Senescence Pathway in Neurodegeneration

metabolic-dysfunction-neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

Cerebral Small Vessel Disease