gene

CXCL10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

929Connections

3Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

CXCL10 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 545 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	CXCL10
Full Name	C-X-C Motif Chemokine Ligand 10
Chromosome	4q21
Function	CXCL10 has essential functions in immune surveillance and inflammation:
Molecular Weight	~10 kDa
Pathways	Akt, Immune Response, Inflammasome, Mapk, Pi3K
NCBI Gene ID	3627
GeneCards	CXCL10
Human Protein Atlas	CXCL10
Protein Class	CXC Chemokine
Cell Type	Expression Level
[Astrocytes](/entities/astrocytes)	High
Microglia	High
Neurons	Moderate
Endothelial cells	High
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer'S Disease
Known Drugs/Compounds	LIRAGLUTIDE
Interactions	TNF, ISG15, STAT1, MMP12, C1Q, CX3CL1
SciDEX Hypotheses	White Matter Oligodendrocyte Protection via CXCL10 White Matter Vulnerability Prevention via Oligoden White Matter Immune Checkpoint Restoration
KG Connections	926 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

🧬 3D Structure: CXCL10 — PDB 1O80 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCL10["CXCL10"] -->|"Activates"| microglia["microglia"]
    CXCL10["CXCL10"] -->|"Participates In"| INTERFERON_RESPONSE["INTERFERON_RESPONSE"]
    CXCL10["CXCL10"] -->|"Interacts With"| CXCR3["CXCR3"]
    CXCL10["CXCL10"] -->|"Activates"| Aging["Aging"]
    CXCL10["CXCL10"] -->|"Activates"| Ms["Ms"]
    CXCL10["CXCL10"] -->|"Regulates"| Als["Als"]
    CXCL10["CXCL10"] -->|"Associated With"| Neurodegeneration["Neurodegeneration"]
    CXCL10["CXCL10"] -->|"Expressed In"| Multiple_Sclerosis["Multiple Sclerosis"]
    FIP200["FIP200"] -->|"Inhibits"| CXCL10["CXCL10"]
    IFN_GAMMA["IFN_GAMMA"] -->|"Activates"| CXCL10["CXCL10"]
    A1_ASTROCYTES["A1_ASTROCYTES"] -->|"Expressed In"| CXCL10["CXCL10"]
    CSF2["CSF2"] -->|"Regulates"| CXCL10["CXCL10"]
    NAMPT["NAMPT"] -->|"Regulates"| CXCL10["CXCL10"]
    style CXCL10 fill:#8d4900,color:#e0e0e0
    style microglia fill:#795548,color:#e0e0e0
    style INTERFERON_RESPONSE fill:#9C27B0,color:#e0e0e0
    style CXCR3 fill:#0d47a1,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Multiple_Sclerosis fill:#b71c1c,color:#e0e0e0
    style FIP200 fill:#0d47a1,color:#e0e0e0
    style IFN_GAMMA fill:#0d47a1,color:#e0e0e0
    style A1_ASTROCYTES fill:#795548,color:#e0e0e0
    style CSF2 fill:#8d4900,color:#e0e0e0
    style NAMPT fill:#8d4900,color:#e0e0e0

Outgoing (576)

Target	Relation	Type	Str
Dermatomyositis	upregulates	disease	0.95
Frailty	biomarker_for	phenotype	0.95
Inflammation	activates	disease	0.95
Psoriatic Arthritis	contributes_to	disease	0.92
Dermatomyositis	biomarker_for	disease	0.90
Interferon-Stimulated Response	involved_in	process	0.90
JAK1/2/STAT1 Signaling	associated_with	pathway	0.90
Keratinocyte SPRY1/CXCL10/Periarticular CD14hi Macrophage/TNF-α Axis	mediates	mechanism	0.90
Th1-Type Response	involved_in	process	0.85
T Cell Infiltration	correlates_with	process	0.85
Immune Cell Recruitment	mediates	process	0.85
Juvenile Dermatomyositis	biomarker_for	disease	0.85
Aging	activates	disease	0.85
Neuroinflammation	involved_in	process	0.85
Als	causes	disease	0.85
CD8+ T cell recruitment	causes (CXCL10 acts as chemokine to recruit cytotoxic CD8+)	mechanism	0.85
Immune Cell Recruitment	associated_with	process	0.80
CD8+ T cells	associated_with	cell_type	0.80
microglia	activates	cell_type	0.80
Multiple Sclerosis	associated_with	disease	0.80
oxidative stress response	participates_in	pathway	0.80
Als	regulates	disease	0.75
Inflammation	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Inflammation	biomarker_for	disease	0.75
Als	biomarker_for	disease	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Multiple Sclerosis	therapeutic_target	disease	0.75
Autoimmune	therapeutic_target	disease	0.75
Tumor	regulates	disease	0.75
Inflammation	implicated_in	disease	0.75
INTERFERON_RESPONSE	participates_in	pathway	0.72
CXCR3	interacts_with	protein	0.72
CXCR3	activates	gene	0.70
CD8	activates	gene	0.70
Nf-Κb	activates	pathway	0.70
Blood-Brain Barrier	activates	pathway	0.70
DNA	activates	gene	0.70
MICROGLIA ACTIVATION	activates	gene	0.70
AGING	activates	gene	0.70
MICROGLIA	activates	gene	0.70
blood-brain barrier	expressed_in	brain_region	0.70
T cells	activates	cell_type	0.70
macrophages	activates	cell_type	0.70
blood-brain barrier	participates_in	pathway	0.70
AGING	regulates	phenotype	0.70
white_matter_degeneration	promotes	phenotype	0.70
Sickle Cell	biomarker_for	disease	0.65
Encephalitis	expressed_in	disease	0.65

Incoming (353)

Source	Relation	Type	Str
SPRY1	inhibits	gene	0.95
A1 Reactive Astrocytes	upregulates	phenotype	0.92
A1 Astrocytes	associated_with	phenotype	0.90
IFNG	upregulates	protein	0.90
Reactive Astrocytes	upregulates	cell_type	0.90
A1 Reactive Astrocytes	associated_with	phenotype	0.90
h-724e3929	targets_gene	hypothesis	0.90
h-245c3e93	targets_gene	hypothesis	0.90
h-c5698ce3	targets_gene	hypothesis	0.90
KCNK2	downregulates	gene	0.85
FIP200	inhibits	protein	0.80
AΒ1-42	alters	compound	0.80
SNCA	alters	gene	0.80
Microglia	upregulates	cell_type	0.80
TNF	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
GENES	activates	gene	0.80
Microglia	associated_with	cell_type	0.78
h-c5698ce3	targets	hypothesis	0.75
STAT1	activates	gene	0.70
TNF	therapeutic_target	gene	0.70
INFLAMMATION	associated_with	gene	0.70
CYTOKINES	activates	gene	0.70
COMPLEMENT	activates	gene	0.70
ASTROCYTES	activates	gene	0.70
IL-6	activates	gene	0.70
CYTOKINES	biomarker_for	gene	0.70
INFLAMMATION	biomarker_for	gene	0.70
CYTOKINES	regulates	gene	0.70
NF-ΚB	activates	gene	0.70
TNF-Α	activates	gene	0.70
IL-6	therapeutic_target	gene	0.70
TNF-Α	therapeutic_target	gene	0.70
ENDOTHELIAL CELLS	inhibits	cell_type	0.70
h-724e3929	targets	hypothesis	0.70
LIRAGLUTIDE	inhibits	drug	0.65
TBK1	causes	gene	0.65
KYNURENINE	inhibits	phenotype	0.65
KYNURENINE	activates	phenotype	0.65
CCL2	associated_with	gene	0.65
MACROPHAGE	produces	cell_type	0.65
IFN_GAMMA	activates	protein	0.64
A1_ASTROCYTES	expressed_in	cell_type	0.64
CSF2	regulates	gene	0.60
NAMPT	regulates	gene	0.60
FGF2	regulates	gene	0.60
CXCL1	inhibits	gene	0.60
FGF21	activates	gene	0.60
APP	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.480	neurodegeneration	Gene expression changes in aging mouse b
White Matter Vulnerability Prevention via Oligodendrocyte Pr	0.468	neurodegeneration	Gene expression changes in aging mouse b
White Matter Immune Checkpoint Restoration	0.418	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (4)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular ma [PMID:41053177]	Lin B, Zhou J, Geng D, Chai S, Zhang X e	Cell Death Differ	2026
Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107]	Lan T, Shang D, Lin L, Wang H, Zou J et	Autophagy	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
Immune checkpoint inhibitor-associated inflammatory arthritis. [PMID:41800958]	Kim ST, Bass AR	Arthritis Rheumatol	2026
Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STIN [PMID:41910318]	Yang LM, Lu Y, Levine MS, Wang X, Shi YQ	J Am Chem Soc	2026
Primary Infection with Cystoisospora suis Modulates Systemic Immunity and the Gu [PMID:41942044]	Ye X, Huang YJ, Deng XL, He ZY, Tan JJ e	Int J Parasitol	2026
CD38 overexpression drives glioblastoma progression via L1CAM/ICAM1/JAK-STAT-Dri [PMID:41946147]	Norouzi S, Aulakh S	Transl Oncol	2026
Differential effects of SARS-CoV-2-targeted infection of ATII, club cells, and m [PMID:41951100]	Todd AW, Shein SA, Korchagina AA, Kudino	Mucosal Immunol	2026
Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408]	Tian X, Liu J, Li Y, Wang Y, Luo Y, He H	Nature	2026
HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707]	da Silva MTT, Araujo AQC	Brain : a journal of neurology	2026
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as [PMID:41941036]	Lai Y, Lin P, Zhang K, Hong W, Zheng M e	Cell Biol Toxicol	2026
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603]	Ye L, Zhao T, Tian H, Li R, Li Z et al.	Sci China Life Sci	2026
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805]	Nie W, Wang M, Cheng M, Ren Z, Liu G et	J Ethnopharmacol	2026

CXCL10

Understanding Entity Pages

Summary

Wiki Pages (21)

CXCL10 - C-X-C Motif Chemokine Ligand 10

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

NF-kB Signaling Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Pathway Diagram

Outgoing (576)

Incoming (353)

Targeting Hypotheses (3)

Mentioning Analyses (4)

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Senolytic therapy for age-related neurodegeneration

Related Papers (20)

CXCL10

Understanding Entity Pages

Summary

Wiki Pages (21)

CXCL10 - C-X-C Motif Chemokine Ligand 10

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

NF-kB Signaling Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Advanced Glycation End Products in Neurodegeneration

Neuroinflammation in Amyotrophic Lateral Sclerosis

IL28B (Interleukin 28B)

Microglia Activation Mechanism

DNA Sensing Pathways in Neurodegeneration

Circadian Rhythm Disruption in Neurodegeneration

Neuroinflammation Pathway

CSF1R Inhibitors for Parkinson's Disease

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

spinocerebellar-ataxia-type-2

Neuroinflammation in Neurodegeneration

Neuroinflammation in Alzheimer and Parkinson Disease

TNF Signaling Pathway in Neurodegeneration

Neuroinflammation and Microglia Pathway

Interferon Signaling in Neurodegeneration

Pathway Diagram

Outgoing (576)

Incoming (353)

Targeting Hypotheses (3)

Mentioning Analyses (4)

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Senolytic therapy for age-related neurodegeneration

Related Papers (20)